Abbisko and AstraZeneca Collaborate on Novel Lung Cancer Therapy
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 6 days ago
0mins
Source: NASDAQ.COM
- Strategic Collaboration: Abbisko has entered into a strategic partnership with AstraZeneca to jointly advance the clinical development of a novel IO-TKI combination therapy for non-small cell lung cancer, aiming to enhance treatment efficacy and address unmet medical needs.
- Clinical Trial Design: The multicenter, open-label Phase I/II study will evaluate Abbisko's first-in-class oral small-molecule PD-L1 inhibitor Lumipodlin in combination with AstraZeneca's EGFR-TKI TAGRISSO, focusing on safety and efficacy in patients with EGFR mutations and PD-L1 positivity.
- Drug Mechanism: Lumipodlin, a novel PD-L1 inhibitor, works by binding to the PD-L1 receptor and inducing its internalization, thereby inhibiting the PD-1/PD-L1 interaction and activating T-cells, with preclinical models showing anti-tumor efficacy comparable to approved PD-L1 antibodies.
- Market Potential: Given that EGFR-mutated patients with high PD-L1 expression derive less benefit from EGFR-TKIs, this combination therapy aims to fill this treatment gap, further enhancing Abbisko's innovative capabilities in oncology.
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Analyst Views on AZN
Wall Street analysts forecast AZN stock price to rise
14 Analyst Rating
13 Buy
0 Hold
1 Sell
Strong Buy
Current: 190.160
Low
157.61
Averages
213.64
High
252.18
Current: 190.160
Low
157.61
Averages
213.64
High
252.18
About AZN
AstraZeneca PLC is a United Kingdom-based science-led biopharmaceutical company. The Company focuses on the discovery, development, and commercialization of prescription medicines. The Company operates across therapy areas, including Oncology; Cardiovascular, Renal and Metabolism (CVRM); Respiratory and Immunology (R&I); Vaccines and Immune Therapies (V&I), and Rare Disease. In the Oncology area, its key products include Tagrisso, Imfinzi, Calquence, Lynparza, and Enhertu. The key products of CVRM area include Farxiga/Forxiga, Brilinta/Brilique, Crestor, and Lokelma. In the R&I area, the key products are Symbicort, Fasenra, Breztri/Trixeo, and Tezspire. In the V&I Therapies area, the products are Beyfortus and FluMist. The products in the Rare Disease area are Ultomiris, Soliris, Strensiq, and Koselugo. It has about 191 projects in its development pipeline, including 19 new molecular entities (NMEs) in the late-stage pipeline. The Company distributes its products in over 125 countries.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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