Lexaria Bioscience Updates on Animal Study Progress
Lexaria Bioscience provides the following update on Animal Study #1 that is evaluating a number of formulation enhancements using both DehydraTECH-semaglutide glucagon-like peptide-1 compositions and DehydraTECH-CBD compositions to explore the potential for additional improved performance as well as stake new intellectual property claims. The Study is on schedule and dosing began on June 10, as planned. Barring any unforeseen interruptions, Study results are currently expected by early September. One of the novel objectives of this Study is to evaluate innovative alternative formulations to SNAC which is currently in use by Novo Nordisk with their oral Rybelsus and Wegovy tablet products. If Lexaria is able to scientifically evidence novel new formulations with similarity or superiority to SNAC performance enhancements, we may be able to establish valuable new proprietary IP and an industry alternative to SNAC that could be of value within the keenly competitive GLP-1 sector. To this end, Lexaria is pleased to report that we have already filed 3 new patent applications that anticipate our latest technological improvements in this area. The Study is utilizing Sprague-Dawley rats with 11 separate Study arms evaluating a number of different novel compositions. Blood samples are being taken at multiple timepoints through an 8-24 hour post-dosing period to quantify the pharmacokinetic performance of each composition. In addition, the Study will also measure drug concentrations in the brain since DehydraTECH has, in the past, evidenced apparent superior absorption of active ingredients into brain tissue, an area of intense interest due to the fact that GLP-1 drug performance is increasingly understood to include or even depend upon involvement of brain neurochemistry, thus making brain biodistribution vital. There will be one reference arm using an existing DHT-sema composition and another reference arm using an existing DHT-CBD composition. Lexaria will leverage the wealth of study data that we have amassed from previous work by utilizing, proprietary historical data and the reference arms as baseline comparators to the current Study results as we search for areas of improvement. The Study is fully funded from existing corporate resources. Lexaria is also reports that on June 11, the company received its first Australian patent grant in Family #21 - Pharmaceutical Compositions and Methods for Treating Hypertension.
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- Significant Study Results: Lexaria achieved the primary endpoint in the GLP-1-H24-4 study, with all four DehydraTECH test arms demonstrating good safety, as DHT-semaglutide showed a 47.9% reduction in adverse events compared to Rybelsus, laying a solid foundation for future clinical applications.
- Adverse Event Reduction: The DHT-semaglutide formulation exhibited a 54.9% reduction in gastrointestinal adverse events, highlighting its safety advantages, which may attract more pharmaceutical companies to consider its product development.
- Funding Support: Lexaria secured approximately $7.5 million through two transactions since August 31, providing a financial runway for prospective new development opportunities in 2026, thereby enhancing its viability in a competitive market.
- Future Plans: Lexaria intends to pursue follow-on clinical testing to explore the potential of a DehydraTECH + SNAC + semaglutide composition, aiming to further validate its application prospects in diabetes treatment.

- Significant Study Results: Lexaria's completed GLP-1-H24-4 study in Australia demonstrated that DHT-semaglutide achieved approximately 47.9% fewer adverse events compared to Novo Nordisk's Rybelsus, indicating its potential in safety and tolerability.
- Reduction in Side Effects: The gastrointestinal adverse events from DHT-semaglutide were reduced by 54.9%, which not only enhances patient experience but also may bolster Lexaria's competitive position in the GLP-1 market.
- Future Research Plans: Lexaria intends to further develop DHT-semaglutide and is considering incorporating salcaprozate sodium in future clinical tests to potentially enhance efficacy and compare it against Rybelsus.
- Data Sharing Agreement: Lexaria will provide the complete dataset from GLP-1-H24-4 to its pharmaceutical partner under a Material Transfer Agreement, which has been extended to April 30, 2026, to ensure adequate time for data review.








