Dianthus Therapeutics Reports 75% Response Rate for Claseprubart
In a regulatory filing, Dianthus Therapeutics reported more data from Part A of its Phase 3 CAPTIVTY study evaluating claseprubart in chronic inflammatory demyelinating polyneuropathy. The company said that claseprubart is "highly potent" classical pathway inhibitor with a roughly 8-week half-life, with clinical and in vitro head-to-head data supporting its potential for a more effective and convenient biologic with no boxed warning. Dianthus said it observed a 75% response rate from the first 40 participants to complete CAPTIVATE Part A, supporting best-in-disease potential, which is higher than the overall rate in the riliprubart Phase 2 at week 24. The company added that mean INCAT score change in responders was at -1.6 at last evaluable visit, and that claseprubart has consistently higher affinity and stronger potency in multiple head-to-head in vitro experiments.
