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IOVA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
4.410
Open
4.250
VWAP
4.28
Vol
11.63M
Mkt Cap
1.94B
Low
4.070
Amount
49.76M
EV/EBITDA(TTM)
--
Total Shares
446.50M
EV
1.56B
EV/OCF(TTM)
--
P/S(TTM)
5.59
Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.
Show More

Events Timeline

(ET)
2026-06-03
16:50:00
Iovance Receives Australian Approval for Amtagvi to Treat Melanoma
select
2026-06-01 (ET)
2026-06-01
08:00:00
Iovance Receives FDA Approval for IOV-5001 Clinical Trial
select
2026-05-07 (ET)
2026-05-07
08:20:00
Iovance Biotherapeutics Sees FY26 Revenue $350M-$370M
select
2026-05-07
08:20:00
Iovance Q1 Revenue at $71.43M, Below Consensus
select
2026-05-07
08:20:00
Amtagvi Sees Q2 Revenue of $79M-$81M
select

News

NASDAQ.COM
6.5
07-04NASDAQ.COM
Investment Comparison: Heartflow vs Iovance
  • Market Positioning: Heartflow focuses on non-invasive AI diagnostics for heart disease, maintaining over 1,450 accounts, with FY 2025 revenue reaching $176 million, a 40% increase, yet reporting a net loss of $116.8 million, indicating high business risk.
  • Product Dependency: Heartflow's FFR CT Analysis product generates 98% of its revenue, creating significant concentration risk, while also facing a U.S. Department of Justice investigation and a potential 15% reduction in Medicare reimbursements in 2026.
  • Growth Potential of Iovance: Iovance Biotherapeutics specializes in personalized tumor-infiltrating lymphocyte therapies, reporting FY 2025 revenue of $263.5 million, a 60.6% growth, despite a net loss of $391 million, with expectations for its products to become blockbusters in the pharmaceutical industry.
  • Financial Health Status: Iovance's debt-to-equity ratio stands at approximately 0.1, indicating a relatively healthy financial structure; however, its negative free cash flow of $336.2 million reflects the high capital demands of personalized cell therapy manufacturing, potentially impacting long-term growth capacity.
Fool
7.5
07-04Fool
Evaluating AI and Personalized Cell Therapy Investment Opportunities
  • Heartflow Financial Performance: Heartflow reported a revenue of $176 million for FY 2025, reflecting a 40% year-over-year increase despite a net loss of $116.8 million, with its core FFR CT Analysis product generating 98% of revenue, indicating strong market demand and growth potential.
  • Iovance Revenue Growth: Iovance achieved a revenue of $263.5 million in FY 2025, marking a 60.6% increase year-over-year, although it recorded a net loss of approximately $391 million; the successful commercialization of its primary products Amtagvi and Proleukin highlights its strong potential in cancer treatment.
  • Risk Analysis: Heartflow faces significant concentration risk due to reliance on a single product, alongside scrutiny from a U.S. Department of Justice investigation and potential Medicare reimbursement cuts, while Iovance contends with a $2.9 billion accumulated deficit and risks associated with its complex manufacturing processes.
  • Valuation Comparison: Neither company is expected to be profitable in 2026, with Heartflow's price-to-sales ratio at 13.8 and Iovance at 5.3, suggesting that Iovance may offer a more attractive risk-adjusted opportunity for investors based on its lower valuation metrics.
Fool
6.5
06-24Fool
Investment Comparison: Amgen vs. Iovance Biotherapeutics
  • Amgen's Stability: In FY 2025, Amgen reported nearly $36.7 billion in revenue, reflecting a 9.9% year-over-year growth, with a net income of approximately $7.7 billion and a net margin of about 21%, showcasing its strong profitability and stability in the global market.
  • Iovance's Growth Potential: Iovance reported revenue of approximately $263.5 million in FY 2025, marking a 60.6% increase, although it faced a net loss of nearly $391 million with a negative net margin of 148.4%, indicating significant investment in its innovative tumor-infiltrating lymphocyte therapies.
  • Risks and Challenges: Amgen is exposed to risks from government pricing regulations and competition from biosimilars, while Iovance must navigate the complexities of manufacturing personalized therapies and uncertainties regarding market adoption, which could impact their future performance.
  • Investment Choice: While Iovance shows rapid growth potential in cancer treatment, Amgen, as a mature biotech firm with stable earnings and consistent dividend payments, may be more suitable for investors seeking lower-risk opportunities.
NASDAQ.COM
6.5
06-24NASDAQ.COM
Comparative Investment Analysis of Amgen and Iovance
  • Amgen's Financial Stability: Amgen reported nearly $36.7 billion in revenue for FY 2025, reflecting a 9.9% increase year-over-year, which supported a net income of approximately $7.7 billion, showcasing its strong market position and profitability across over 50 countries.
  • Iovance's Growth Potential: Iovance achieved approximately $263.5 million in revenue for FY 2025, a 60.6% increase, despite a net loss of nearly $391 million, indicating that its innovative tumor-infiltrating lymphocyte therapies could offer significant market expansion opportunities in the future.
  • Risks and Challenges: Amgen faces risks from government pricing regulations and competition from biosimilars, while Iovance must navigate the complexities of manufacturing personalized therapies and uncertainties regarding market adoption, which could impact their future profitability.
  • Investor Considerations: Investors must weigh the stability of Amgen against the high-reward potential of Iovance, with Amgen appealing to conservative investors due to its steady earnings and dividends, while Iovance may attract those seeking high-risk, high-reward opportunities.
Yahoo Finance
6.5
06-24Yahoo Finance
Amgen vs Iovance: Investment Comparison
  • Amgen's Stability: In FY 2025, Amgen reported nearly $36.7 billion in revenue, a 9.9% increase year-over-year, with a net income of approximately $7.7 billion and a net margin of about 21%, showcasing its strong profitability and stability in the global market.
  • Iovance's Rapid Growth: Iovance achieved approximately $263.5 million in revenue for FY 2025, marking a 60.6% increase, yet it reported a net loss of nearly $391 million, indicating its innovative potential in cancer treatment but highlighting its lack of profitability.
  • Risk Comparison: Amgen faces risks from government pricing regulations and competition from biosimilars, while Iovance must navigate the complexities of manufacturing personalized therapies and uncertainties regarding market adoption, which could impact their future market performance.
  • Valuation Differences: Amgen has a forward P/E ratio of 15.1, reflecting its value as a mature company, whereas Iovance, still unprofitable, has a P/S ratio of 5.4, indicating its high-risk investment profile in the early growth stage.
Yahoo Finance
8.5
06-18Yahoo Finance
Iovance Biotherapeutics Files Registration Statement for sec
  • Registration Statement Filed: Iovance Biotherapeutics filed a registration statement on Thursday, marking the formal initiation of its potential sale, although specific sales details remain undisclosed, indicating the company's proactive stance in the biotherapeutics sector.
  • Market Reaction Anticipated: The filing of this registration statement may prompt market interest in Iovance's future financing capabilities, particularly against the backdrop of increasing competition in the biopharmaceutical industry, with investors eager to gauge the market potential of its products.
  • Strategic Implications: By submitting the registration statement, Iovance may be paving the way for future capital operations, especially in advancing its therapeutic solutions through clinical trials and market promotion, reflecting the company's confidence in its future development.
  • Industry Context: The biotherapeutics sector is experiencing rapid growth, and Iovance's registration statement could attract more investor attention, further driving its innovation and market share in the cell therapy domain.
Wall Street analysts forecast IOVA stock price to rise
8 Analyst Rating
Wall Street analysts forecast IOVA stock price to rise
6 Buy
1 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Chardan
Buy
maintain
$16 -> $14
AI Analysis
2026-05-07
Reason
Chardan
Price Target
$16 -> $14
AI Analysis
2026-05-07
maintain
Buy
Reason
Chardan lowered the firm's price target on Iovance Biotherapeutics to $14 from $16 and keeps a Buy rating on the shares. The firm is adjusting its model to reflect the updated Amtagvi launch guidance, the analyst tells investors in a research note.
Jefferies
Andrew Tsai
Buy
maintain
$12
2026-04-10
Reason
Jefferies
Andrew Tsai
Price Target
$12
2026-04-10
maintain
Buy
Reason
Jefferies analyst Andrew Tsai noted that the FDA has issued another complete response letter rejection to Replimune (REPL) for Tudriqev in second-line advanced melanoma. Although Replimune was "technically not an overhang" on Iovance Biotherapeutics (IOVA) stock, the situation does mean one less competitor in the near-term, says the analyst, who can see a potential 5%-15% stock move on the news. The firm, which adds that the Iovance story "remains centered on" Amtagvi's sales acceleration and margin expansion in 2026, has a Buy rating and $12 price target on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IOVA
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Valuation Metrics

The current forward P/E ratio for Iovance Biotherapeutics Inc (IOVA.O) is 0.00, compared to its 5-year average forward P/E of -5.83. For a more detailed relative valuation and DCF analysis to assess Iovance Biotherapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.83
Current PE
0.00
Overvalued PE
-2.95
Undervalued PE
-8.71

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.68
Current EV/EBITDA
-3.45
Overvalued EV/EBITDA
-1.84
Undervalued EV/EBITDA
-7.52

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
43.21
Current PS
3.88
Overvalued PS
171.22
Undervalued PS
-84.80

Financials

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Invenomic Capital Management LP
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IOVA
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Frequently Asked Questions

What is Iovance Biotherapeutics Inc (IOVA) stock price today?

The current price of IOVA is 4.35 USD — it has increased 3.82

What is Iovance Biotherapeutics Inc (IOVA)'s business?

Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.

What is the price predicton of IOVA Stock?

Wall Street analysts forecast IOVA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IOVA is9.50 USD with a low forecast of 1.50 USD and a high forecast of 17.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Iovance Biotherapeutics Inc (IOVA)'s revenue for the last quarter?

Iovance Biotherapeutics Inc revenue for the last quarter amounts to 71.43M USD, increased 44.82

What is Iovance Biotherapeutics Inc (IOVA)'s earnings per share (EPS) for the last quarter?

Iovance Biotherapeutics Inc. EPS for the last quarter amounts to -0.19 USD, decreased -47.22

How many employees does Iovance Biotherapeutics Inc (IOVA). have?

Iovance Biotherapeutics Inc (IOVA) has 975 emplpoyees as of July 08 2026.

What is Iovance Biotherapeutics Inc (IOVA) market cap?

Today IOVA has the market capitalization of 1.94B USD.