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MNPR Overview

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0.000(0.000%)Aft-market
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0.000
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ET
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Intellectia

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High
98.955
Open
97.110
VWAP
96.01
Vol
163.57K
Mkt Cap
637.88M
Low
93.855
Amount
15.70M
EV/EBITDA(TTM)
--
Total Shares
6.70M
EV
513.12M
EV/OCF(TTM)
--
P/S(TTM)
--
Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company. The Company developing treatments for Wilson disease and novel radiopharmaceuticals for oncology. The Company’s product candidates are ALXN1840, MNPR-101, MNPR-101-Zr, MNPR-101-Lu, and MNPR-101-Ac. The Company’s Wilson disease product candidate is ALXN1840, a late-stage, investigational once-daily, oral medicine. Its radiopharmaceutical program consists of MNPR-101, a proprietary humanized monoclonal antibody that is being developed across multiple product candidates conjugated with different radioisotopes, for the treatment of advanced solid tumors. MNPR-101-Zr is the Company’s clinical-stage radiodiagnostic imaging agent comprised of MNPR-101 conjugated to zirconium-89. MNPR-101-Lu is its clinical-stage radiotherapeutic comprised of MNPR-101 conjugated to lutetium-177. MNPR-101-Ac is late-preclinical stage radiotherapeutic comprised of MNPR-101 conjugated to actinium-225.
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Events Timeline

(ET)
2026-06-30
08:30:00
Monopar Therapeutics ALXN1840 Receives FDA Rare Pediatric Disease Designation
select
2026-06-26 (ET)
2026-06-26
16:30:00
Monopar Therapeutics to Present ALXN1840 Study Analysis at EAN 2026
select
2026-06-01 (ET)
2026-06-01
07:30:00
Monopar Therapeutics Presents Phase 2 ALXN1840 Data at EASL 2026
select
2026-04-19 (ET)
2026-04-19
20:50:00
Monopar Therapeutics Releases New Data on ALXN1840 Study
select
2026-03-02 (ET)
2026-03-02
08:10:00
Monopar Therapeutics Appoints Susan Rodriguez as Chief Commercial and Strategy Officer
select

News

NASDAQ.COM
9.0
06-30NASDAQ.COM
Monopar Therapeutics Receives FDA Rare Pediatric Disease Designation
  • FDA Designation Progress: Monopar Therapeutics announced that its late-stage candidate ALXN1840 has received Rare Pediatric Disease (RPD) designation from the FDA, marking a significant milestone in the treatment of Wilson disease.
  • Focus on Pediatric Diseases: The RPD designation specifically targets serious or life-threatening diseases affecting children from birth to 18 years, highlighting the company's commitment to addressing children's health issues and its social responsibility in the biopharmaceutical sector.
  • Priority Review Potential: With the RPD designation, Monopar has the opportunity to receive a pediatric Priority Review Voucher (PRV) at the time of New Drug Application (NDA) approval, which can expedite the review process for subsequent marketing applications, potentially shortening the FDA's review timeline.
  • Market Opportunity Expansion: The RPD designation not only enhances Monopar's product competitiveness but also opens avenues for additional financial benefits through the transfer or sale of the PRV, further supporting its research and development and market expansion strategies.
Newsfilter
9.0
06-30Newsfilter
Monopar Receives Rare Pediatric Disease Designation
  • FDA Designation Progress: Monopar Therapeutics announced that its candidate ALXN1840 for Wilson disease has received Rare Pediatric Disease (RPD) designation from the FDA, aimed at accelerating the development of treatments for serious diseases affecting children, which is expected to provide the company with a Priority Review Voucher for expedited drug application approval, significantly reducing review timelines.
  • Wilson Disease Background: Wilson disease is a rare genetic disorder affecting approximately 1 in 30,000 people globally, leading to toxic copper accumulation in the body, which can be fatal if untreated, underscoring the urgent need for new treatment options and further driving the development of ALXN1840.
  • Clinical Trial Results: In the Phase 3 pivotal trial, ALXN1840 demonstrated rapid and sustained copper mobilization significantly superior to standard care, with durable clinical improvement and a favorable safety profile observed across 645 patient-years in 266 patients, indicating its potential in treating Wilson disease.
  • Strategic Implications: This FDA designation not only enhances Monopar's reputation in the biopharmaceutical sector but may also create favorable conditions for future financing and market acceptance, strengthening its position in the competitive pharmaceutical landscape.
Newsfilter
8.5
06-26Newsfilter
Monopar Announces New Analyses of ALXN1840 Clinical Trial Results
  • Clinical Trial Results: Monopar presented new analyses from the Phase 3 FoCus trial of ALXN1840 at the 2026 European Academy of Neurology Congress, demonstrating that the drug significantly outperformed standard care in copper mobilization, indicating its potential clinical benefits for Wilson disease patients.
  • Significant Neurologic Improvement: Among 207 patients with baseline neurologic symptoms, ALXN1840 showed significant improvement on the Unified Wilson Disease Rating Scale (UWDRS) Part III (p=0.006), while standard care did not demonstrate similar improvements, highlighting the drug's efficacy.
  • Global Clinical Improvement: At Week 48, ALXN1840 achieved significantly greater improvement on the Clinical Global Impressions – Improvement (CGI-I) scale compared to standard care (p<0.001), suggesting its advantages in clinical application and potential for increased market acceptance.
  • Favorable Safety Profile: Across 266 patients in Phase 2 and Phase 3 studies, ALXN1840 exhibited a favorable safety profile with drug-related serious adverse events occurring in only 4.9%, providing strong support for its upcoming NDA submission to the FDA.
NASDAQ.COM
8.5
06-24NASDAQ.COM
Boundless Bio Merges with Serapha in All-Stock Deal
  • Merger Overview: Boundless Bio has agreed to merge with privately held Serapha Bio in an all-stock transaction expected to close in Q4 2026, with the combined entity to operate under the name Serapha Bio, Inc. and trade on Nasdaq as "AATD", enhancing its competitive position in the biopharmaceutical market.
  • Cash Dividend Plan: Prior to the merger's completion, Boundless Bio plans to declare a cash dividend to existing shareholders, aimed at boosting shareholder confidence and laying a solid foundation for the upcoming merger, which is expected to attract more investor interest.
  • Clinical Candidate Development: Serapha's lead clinical candidate, SERP-01, is being developed for severe Alpha-1 Antitrypsin Deficiency, which is anticipated to provide new revenue streams for the company and strengthen its market position in the therapeutic area.
  • Stock Performance: Boundless Bio's stock surged 85.71% to close at $2.60, reflecting a positive market reaction to the merger news and indicating investor optimism regarding future growth potential.
NASDAQ.COM
8.5
05-22NASDAQ.COM
Biotech Sector Regulatory Approvals and Collaborations
  • Kidney Cancer Treatment Breakthrough: HUTCHMED and Innovent received NMPA approval in China for the ELUNATE-TYVYT combination therapy, supported by the FRUSICA-2 study showing a 63% reduction in disease progression or death risk, with a median progression-free survival of 22.2 months, significantly improving patient outcomes and enhancing market competitiveness.
  • Antibiotic Market Expansion: Sunshine Biopharma received Canadian approval for its generic Amoxicillin, with shipments expected to begin in August 2026, aiming to increase access to high-quality antibiotics for treating common infections, which is anticipated to drive revenue growth for the company.
  • Liquid Biopsy Technology Innovation: Guardant Health gained FDA approval for Guardant360 Liquid CDx, now the largest liquid biopsy panel with a genomic footprint 100 times broader than its predecessor, enhancing tumor profiling capabilities and expected to boost the company's market share in precision medicine.
  • New Hypertension Drug Launch: AstraZeneca received FDA approval for BAXFENDY for hypertension patients, based on positive results from the BaxHTN Phase III trial, which is expected to strengthen the company's competitive position in the cardiovascular drug market and further expand its product line.
NASDAQ.COM
9.0
05-20NASDAQ.COM
Monopar Therapeutics Publishes Phase 2 Results for ALXN1840 in Wilson Disease
  • Clinical Trial Results: Monopar Therapeutics announced that the Phase 2 open-label trial of ALXN1840 in patients with Wilson disease demonstrated a significant average reduction of 6.08 mg in copper balance after 21 days of daily dosing, indicating the drug's efficacy in copper metabolism regulation.
  • Innovative Drug Mechanism: ALXN1840, as the first Albumin Tripartite Complex (ATC) activator, mobilizes and sequesters copper, suppressing its redox reactivity and limiting its transport across the blood-brain barrier, showcasing a unique therapeutic mechanism.
  • Good Tolerability: The trial indicated that ALXN1840 was generally well-tolerated with no serious adverse events reported, highlighting its safety in clinical applications and laying a foundation for future market promotion.
  • Optimistic Market Outlook: With ALXN1840 showing significant copper mobilization effects in a completed 48-week Phase 3 trial involving 266 patients, the drug is poised to become a new standard in Wilson disease treatment, further enhancing Monopar's competitive position in the market.
Wall Street analysts forecast MNPR stock price to rise
11 Analyst Rating
Wall Street analysts forecast MNPR stock price to rise
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
95.00
Averages
112.91
High
130.00
Current: 0.000
sliders
Low
95.00
Averages
112.91
High
130.00
BTIG
Jeet Mukherjee
Buy
maintain
$104 -> $117
AI Analysis
2026-07-01
Reason
BTIG
Jeet Mukherjee
Price Target
$104 -> $117
AI Analysis
2026-07-01
maintain
Buy
Reason
BTIG analyst Jeet Mukherjee raised the firm's price target on Monopar Therapeutics to $117 from $104 and keeps a Buy rating on the shares. Monopar has an improved regulatory outlook ahead of its planned NDA submission for ALXN1840 in Wilson's disease, supported by recent FDA signals and draft guidance suggesting greater willingness to accept a single high-quality Phase 3 trial with confirmatory evidence for rare disease approvals, the analyst tells investors in a research note.
BTIG
Jeet Mukherjee
Buy
maintain
$104 -> $117
2026-06-30
Reason
BTIG
Jeet Mukherjee
Price Target
$104 -> $117
2026-06-30
maintain
Buy
Reason
BTIG analyst Jeet Mukherjee raised the firm's price target on Monopar Therapeutics to $117 from $104 and keeps a Buy rating on the shares. Monopar has an improved regulatory outlook ahead of its planned NDA submission for ALXN1840 in Wilson's disease, supported by recent FDA signals suggesting greater flexibility for rare disease approvals based on a single high-quality Phase 3 trial plus confirmatory evidence, alongside broader regulatory reversals in the rare disease space, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for MNPR
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Valuation Metrics

The current forward P/E ratio for Monopar Therapeutics Inc (MNPR.O) is 0.00, compared to its 5-year average forward P/E of -6.30. For a more detailed relative valuation and DCF analysis to assess Monopar Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.30
Current PE
0.00
Overvalued PE
1.31
Undervalued PE
-13.92

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
2.45
Current PS
41.05
Overvalued PS
9.87
Undervalued PS
-4.98

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Whales Holding MNPR

R
RA Capital Management, L.P.
Holding
MNPR
+14.27%
3M Return
A
ADAR1 Capital Management, LLC
Holding
MNPR
+4.60%
3M Return

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Frequently Asked Questions

What is Monopar Therapeutics Inc (MNPR) stock price today?

The current price of MNPR is 95.22 USD — it has decreased -1.96

What is Monopar Therapeutics Inc (MNPR)'s business?

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company. The Company developing treatments for Wilson disease and novel radiopharmaceuticals for oncology. The Company’s product candidates are ALXN1840, MNPR-101, MNPR-101-Zr, MNPR-101-Lu, and MNPR-101-Ac. The Company’s Wilson disease product candidate is ALXN1840, a late-stage, investigational once-daily, oral medicine. Its radiopharmaceutical program consists of MNPR-101, a proprietary humanized monoclonal antibody that is being developed across multiple product candidates conjugated with different radioisotopes, for the treatment of advanced solid tumors. MNPR-101-Zr is the Company’s clinical-stage radiodiagnostic imaging agent comprised of MNPR-101 conjugated to zirconium-89. MNPR-101-Lu is its clinical-stage radiotherapeutic comprised of MNPR-101 conjugated to lutetium-177. MNPR-101-Ac is late-preclinical stage radiotherapeutic comprised of MNPR-101 conjugated to actinium-225.

What is the price predicton of MNPR Stock?

Wall Street analysts forecast MNPR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MNPR is112.91 USD with a low forecast of 95.00 USD and a high forecast of 130.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Monopar Therapeutics Inc (MNPR)'s revenue for the last quarter?

Monopar Therapeutics Inc revenue for the last quarter amounts to -5.22M USD, increased 62.18

What is Monopar Therapeutics Inc (MNPR)'s earnings per share (EPS) for the last quarter?

Monopar Therapeutics Inc. EPS for the last quarter amounts to -3473906.00 USD, decreased -38.66

How many employees does Monopar Therapeutics Inc (MNPR). have?

Monopar Therapeutics Inc (MNPR) has 22 emplpoyees as of July 08 2026.

What is Monopar Therapeutics Inc (MNPR) market cap?

Today MNPR has the market capitalization of 637.88M USD.