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NGNE Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
37.070
Open
32.990
VWAP
35.29
Vol
708.53K
Mkt Cap
710.31M
Low
32.000
Amount
25.00M
EV/EBITDA(TTM)
--
Total Shares
19.30M
EV
399.59M
EV/OCF(TTM)
--
P/S(TTM)
--
Neurogene Inc. is a clinical-stage biotechnology company. The Company, through its proprietary transgene regulation technology, Expression Attenuation via Construct Tuning (EXACT), is building a product portfolio of genetic medicines for rare neurological diseases with high unmet needs not otherwise addressable by conventional gene therapy. Its clinical-stage program, NGN-401, utilize the EXACT platform, which is in development for the treatment of Rett syndrome, a disease with a patient population that has a significant unmet need, and that ultimately progresses to substantial neurological and physical impairment and premature death. NGN-401 is being evaluated in female patients with Rett syndrome in a Phase 1/2 open-label, multi-center clinical trial that assesses the safety, tolerability, and efficacy of two doses of NGN-401 delivered using a one-time intracerebral ventricular (ICV) procedure. It is also developing NGN-101 for the treatment of CLN5 Batten disease.
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Events Timeline

(ET)
2026-07-01
07:30:00
Neurogene Prices Public Offering at $30 per Share
select
2026-06-30 (ET)
2026-06-30
19:00:00
Leerink and Others Act as Joint Book Running Managers for Offering
select
2026-06-30
16:30:00
Neurogene Commences Public Offering of Shares
select
2026-06-29 (ET)
2026-06-29
07:30:00
Neurogene Updates Positive Data on NGN-401 Clinical Trial
select
2026-05-12 (ET)
2026-05-12
16:20:00
Neurogene Cash Reserves Reach $243.2 Million to Support NGN-401 Development
select
2026-04-20 (ET)
2026-04-20
07:40:00
Neurogene Appoints Christy Shafer as Chief Commercial Officer
select

News

seekingalpha
8.5
07-01seekingalpha
Neurogene Prices Public Offering of 3.5M Shares at $30 Each
  • Offering Details: Neurogene priced a public offering of 3.5 million common shares at $30.00 each, alongside 666,666 pre-funded warrants for certain investors, which can be exercised immediately at $0.000001 per share, indicating the company's proactive approach to capitalizing on market opportunities.
  • Expected Fundraising: The offering is anticipated to raise approximately $125 million in gross proceeds before expenses, which will be utilized to support the company's future research and operations, thereby advancing its gene therapy projects significantly.
  • Underwriter's Option: The company granted underwriters a 30-day option to purchase up to an additional 624,999 shares to cover overallotments, a strategy that provides flexibility in financing and enhances market demand for its stock.
  • Closing Timeline: The public offering is scheduled to close on July 2, 2026, subject to customary closing conditions, providing investors with a clear timeline for their investment while laying the groundwork for the company's future capital operations.
seekingalpha
8.5
06-30seekingalpha
Neurogene Launches Public Offering to Fund NGN-401 Development
  • Public Offering Initiated: Neurogene (NGNE) has commenced a public offering of common stock, allowing certain investors to purchase pre-funded warrants, indicating a positive market response to its financing strategy.
  • Underwriter Option: The company expects to grant underwriters a 30-day option to purchase additional shares, enhancing the flexibility of capital raising and potentially supporting future financing efforts.
  • Clear Use of Proceeds: The proceeds will fund the clinical development and pre-commercial activities of NGN-401, along with working capital and general corporate purposes, ensuring sustained investment in R&D and operations.
  • Increased Market Attention: As Neurogene progresses in gene therapy for Rett syndrome, investor interest in its future potential is rising, which may drive positive stock performance.
NASDAQ.COM
2.0
06-29NASDAQ.COM
Neurogene Reports Positive Long-Term Data for NGN-401 in Rett Syndrome
  • Clinical Trial Results: Neurogene's Phase 1/2 study of NGN-401 for Rett syndrome showed that 10 participants achieved a total of 47 developmental milestones, averaging 4.7 milestones per patient, indicating significant efficacy of the therapy.
  • Sustained Improvement: All participants improved on the Clinical Global Impression-Improvement (CGI-I) scale, with no loss of milestones reported during the 30-month follow-up, demonstrating the durability of the treatment effects.
  • Key Metrics Progress: Participants exhibited progressive improvements across key Rett syndrome measures, with a median time to first clinical improvement of two months post-treatment, highlighting the rapid responsiveness of the therapy.
  • Good Safety Profile: As of June 16, 2026, no treatment-related serious adverse events or dose-limiting toxicities were reported in the Embolden registrational trial, further reinforcing confidence in the therapy's safety.
Newsfilter
8.5
06-08Newsfilter
Neurogene Exceeds Dosing Target in NGN-401 Trial
  • Dosing Overachievement: Neurogene has successfully dosed 25 participants in the Embolden™ registrational trial of NGN-401, exceeding the initial target of 20 due to strong demand from the Rett syndrome community, highlighting the significant unmet need in this area.
  • Good Tolerability: As of June 7, 2026, NGN-401 at the 1E15 vg dose has been generally well-tolerated among 35 participants, with no cases of hemophagocytic lymphohistiocytosis (HLH) reported, indicating satisfactory safety and tolerability for this treatment.
  • Data Release Expectations: Neurogene anticipates sharing topline data from the Embolden trial in the second half of 2027, which will serve as the primary analysis for the planned Biologics License Application (BLA), with a required success threshold of a 33% response rate.
  • Clinical Development Outlook: NGN-401 is viewed as a potential best-in-class treatment, with Neurogene planning to present updated interim data from the Phase 1/2 trial in mid-2026, further supporting its application potential in treating Rett syndrome.
seekingalpha
9.5
05-12seekingalpha
Neurogene Q1 Earnings Miss Expectations with GAAP EPS of -$1.39
  • Earnings Performance: Neurogene reported a Q1 GAAP EPS of -$1.39, missing expectations by $0.09, indicating challenges in profitability that could affect investor confidence moving forward.
  • Cash Reserves: As of March 31, 2026, Neurogene's cash, cash equivalents, and short-term investments totaled $243.2 million, which is expected to fund operations through Q1 2028, reflecting a degree of stability in financial management.
  • FDA Designation Impact: Despite the disappointing earnings report, Neurogene's stock soared following FDA designation for its Rett syndrome gene therapy, demonstrating market confidence in its potential products and possibly providing momentum for future growth.
  • Cautious Investment Advice: Although the stock price surged due to FDA designation, analysts recommend that investors remain cautious given the company's current financial performance and uncertainties ahead, which may impact long-term investment decisions.
Newsfilter
8.5
05-12Newsfilter
Neurogene Advances Gene Therapy with ICV Administration
  • ICV Administration Benefits: Neurogene's use of intracerebroventricular (ICV) administration in gene therapy demonstrates broad brain biodistribution, enhancing treatment efficacy, particularly showing multidomain durable improvements in the clinical trial for Rett syndrome.
  • Clinical Trial Results: In the Phase 1/2 trial, all eight pediatric participants receiving the 1E15 vg dose exhibited functional improvements, achieving a total of 35 developmental milestones with no plateau observed up to 24 months, indicating the therapy's effectiveness and good tolerability.
  • Simplicity of Procedure: The ICV administration procedure takes approximately 10 minutes and is performed tens of thousands of times annually by pediatric and adult neurosurgeons, showcasing its routine clinical application and safety, further enhancing the potential for NGN-401's clinical use.
  • Regulatory Recognition: NGN-401 has received multiple designations from the FDA, including Breakthrough Therapy and Regenerative Medicine Advanced Therapy, underscoring its significance and market potential in treating Rett syndrome, with expectations of substantial quality-of-life improvements for patients.
Wall Street analysts forecast NGNE stock price to rise
5 Analyst Rating
Wall Street analysts forecast NGNE stock price to rise
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
46.00
Averages
58.00
High
70.00
Current: 0.000
sliders
Low
46.00
Averages
58.00
High
70.00
Rodman & Renshaw
Buy
initiated
$70
AI Analysis
2026-06-03
Reason
Rodman & Renshaw
Price Target
$70
AI Analysis
2026-06-03
initiated
Buy
Reason
Rodman & Renshaw initiated coverage of Neurogene with a Buy rating and $70 price target, implying 170% upside from current levels. The company's lead asset, NGN-401, is a one-time AAV9 gene therapy gene therapy for Rett syndrome, a rare neurodevelopmental disorder with no disease modifying treatments, the analyst tells investors in a research note. The firm believes NGN-401 only needs to capture a fraction of the multi-billion Rett market to support substantial upside from current share levels.
Guggenheim
Buy
initiated
$69
2026-04-28
Reason
Guggenheim
Price Target
$69
2026-04-28
initiated
Buy
Reason
Guggenheim initiated coverage of Neurogene with a Buy rating and $69 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for NGNE
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Valuation Metrics

The current forward P/E ratio for Neurogene Inc (NGNE.O) is 0.00, compared to its 5-year average forward P/E of -6.03. For a more detailed relative valuation and DCF analysis to assess Neurogene Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.03
Current PE
0.00
Overvalued PE
-3.43
Undervalued PE
-8.64

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
114.42
Current PS
0.00
Overvalued PS
430.16
Undervalued PS
-201.32

Financials

AI Analysis
Annual
Quarterly

Whales Holding NGNE

L
Logos Global Management, L.P.
Holding
NGNE
+27.09%
3M Return
R
Redmile Group, LLC
Holding
NGNE
+22.75%
3M Return
E
EcoR1 Capital, LLC
Holding
NGNE
+20.86%
3M Return

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Frequently Asked Questions

What is Neurogene Inc (NGNE) stock price today?

The current price of NGNE is 36.8 USD — it has increased 13.02

What is Neurogene Inc (NGNE)'s business?

Neurogene Inc. is a clinical-stage biotechnology company. The Company, through its proprietary transgene regulation technology, Expression Attenuation via Construct Tuning (EXACT), is building a product portfolio of genetic medicines for rare neurological diseases with high unmet needs not otherwise addressable by conventional gene therapy. Its clinical-stage program, NGN-401, utilize the EXACT platform, which is in development for the treatment of Rett syndrome, a disease with a patient population that has a significant unmet need, and that ultimately progresses to substantial neurological and physical impairment and premature death. NGN-401 is being evaluated in female patients with Rett syndrome in a Phase 1/2 open-label, multi-center clinical trial that assesses the safety, tolerability, and efficacy of two doses of NGN-401 delivered using a one-time intracerebral ventricular (ICV) procedure. It is also developing NGN-101 for the treatment of CLN5 Batten disease.

What is the price predicton of NGNE Stock?

Wall Street analysts forecast NGNE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NGNE is58.00 USD with a low forecast of 46.00 USD and a high forecast of 70.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Neurogene Inc (NGNE)'s revenue for the last quarter?

Neurogene Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Neurogene Inc (NGNE)'s earnings per share (EPS) for the last quarter?

Neurogene Inc. EPS for the last quarter amounts to -1.39 USD, increased 28.70

How many employees does Neurogene Inc (NGNE). have?

Neurogene Inc (NGNE) has 131 emplpoyees as of July 08 2026.

What is Neurogene Inc (NGNE) market cap?

Today NGNE has the market capitalization of 710.31M USD.