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PRQR Overview

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0.000
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Intellectia

Loading chart...

High
1.699
Open
1.650
VWAP
1.63
Vol
1.09M
Mkt Cap
234.26M
Low
1.590
Amount
1.79M
EV/EBITDA(TTM)
--
Total Shares
141.12M
EV
153.24M
EV/OCF(TTM)
--
P/S(TTM)
11.50
ProQR Therapeutics N.V. is a biotechnology company based in the Netherlands. The Company is engaged in the discovery and development of ribonucleic Acid (RNA)-based therapeutics for the treatment of severe genetic disorders. Main purpose of the Company is advancement of its Axiomer RNA-editing platform technology. That technology uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unaddressed needs. The Company operates research pipeline that contains of RNA Therapy and AX-0810 Cholestatic Diseases (NTCP).
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Events Timeline

(ET)
2026-07-06
16:30:00
Company Does Not Sell 3.03M Ordinary Shares
select
2026-06-25 (ET)
2026-06-25
07:00:00
ProQR Therapeutics Prices 27.6M Share Offering at $1.81
select
2026-06-25
07:00:00
ProQR Therapeutics Reports Positive Phase 1 Data for AX-0810
select

News

NASDAQ.COM
8.5
06-26NASDAQ.COM
ProQR Announces Underwritten Direct Offering, Shares Drop 20%
  • Offering Overview: ProQR Therapeutics announced the completion of an underwritten registered direct offering of 27,624,810 ordinary shares at $1.1 per share, with gross proceeds estimated at $50 million, indicating an urgent need for financing amid market pressures.
  • Strategic Partnership Agreement: Concurrently, the company entered into a purchase agreement with strategic partner Eli Lilly for 5,100,780 ordinary shares, expected to generate $9.2 million, aimed at strengthening collaboration and funding future research initiatives.
  • Use of Proceeds: ProQR plans to allocate the proceeds from this offering to fund research and clinical development of current or additional pipeline candidates, as well as for working capital, capital expenditures, and other general corporate purposes, highlighting the company's commitment to R&D.
  • Market Reaction Analysis: Despite a significant drop of over 20% in share price on Thursday, closing at $1.44, shares showed a slight recovery in pre-market trading to $1.57, reflecting a complex market reaction and cautious investor sentiment regarding the company's future prospects.
seekingalpha
8.5
06-25seekingalpha
ProQR Therapeutics Prices $50M Direct Offering of 27.6M Shares
  • Offering Size: ProQR Therapeutics has priced a registered direct offering of 27.6 million ordinary shares at $1.81 per share, aiming to raise approximately $50 million in gross proceeds before expenses to support its research and clinical development initiatives.
  • Strategic Partnership: Existing shareholder Eli Lilly has agreed to purchase 5.1 million ordinary shares at the same price, valued at about $9.2 million, which will help Lilly maintain its pro rata beneficial ownership and further solidify their strategic partnership.
  • Use of Proceeds: ProQR plans to utilize the proceeds from both transactions, along with its existing cash, to fund research, clinical development, working capital, capital expenditures, and other general corporate purposes, ensuring the company's ongoing operations and growth.
  • Market Reaction: Following the financing announcement, ProQR shares rose by 1.48% in premarket trading, indicating a positive market response to the company's financing plans, which may enhance investor confidence.
seekingalpha
9.0
06-25seekingalpha
ProQR Therapeutics Reports Positive Phase 1 Data for AX-0810
  • Clinical Trial Results: ProQR Therapeutics announced that its Phase 1 trial for AX-0810, involving 22 healthy volunteers, demonstrated a favorable safety and tolerability profile, with no serious adverse events reported, indicating the therapy's potential in liver disease treatment.
  • Mechanism of Action: AX-0810 modulates NTCP, a bile acid transporter, resulting in up to an eight-fold increase in serum bile acids, significantly exceeding the predefined two-fold threshold, which confirms its effectiveness as a novel therapeutic target.
  • Market Potential: The data supports ProQR's advancement of its NTCP franchise, including AX-0810 and its sister therapy, particularly targeting biliary atresia, a cholestatic liver disease, suggesting promising future market opportunities.
  • Strategic Partnerships: ProQR has formed a partnership with Ginkgo as part of its AI strategy, aimed at accelerating drug development and market entry, thereby enhancing its competitive position in the biotech sector.
NASDAQ.COM
9.0
06-25NASDAQ.COM
ProQR Reports Positive Data from AX-0810 Phase 1 Study
  • Clinical Trial Progress: ProQR Therapeutics N.V. has enrolled 33 healthy volunteers in its Phase 1 study of AX-0810, with 24 receiving the treatment, demonstrating good safety and tolerability, indicating potential for future research.
  • Biomarker Results: In the 3 mg/kg and 6 mg/kg cohorts, AX-0810 resulted in up to an 8-fold increase in total bile acids in serum, exceeding the company's predefined target of 2-fold, showcasing effective NTCP modulation and potential new avenues for treating liver-related diseases.
  • Increased Urinary Excretion: The administration of AX-0810 led to statistically significant increases in urinary excretion of conjugated bile acids, suggesting that the drug may lower toxic bile acid concentrations in the body through NTCP modulation, thereby improving liver health.
  • Future Development Plans: ProQR intends to submit a Clinical Trial Application for AX-0811 in mid-2026 and anticipates initial human clinical data by the end of 2026, reflecting the company's ongoing investment and commitment to research in the NTCP space.
Newsfilter
9.0
06-25Newsfilter
Positive Phase 1 Study Results for AX-0810 Indicate Significant NTCP Modulation
  • Dose-Dependent Target Engagement: AX-0810 demonstrated up to an 8-fold increase in total bile acids in serum at 3 mg/kg and 6 mg/kg doses, exceeding the company's 2-fold threshold for meaningful NTCP modulation, indicating potential new treatment avenues for cholestatic liver diseases like biliary atresia.
  • Favorable Safety and Tolerability: To date, AX-0810 has shown no serious adverse events or pruritus in the clinical trial, reflecting a favorable safety profile, while pharmacokinetic data indicate a sustained target engagement with an 8-week half-life, enhancing its clinical applicability.
  • Biomarker Findings Support Further Research: The biomarker results from AX-0810 support the advancement of the next-generation candidate AX-0811, which has shown significant cholestasis reduction in animal models, with a Clinical Trial Application expected in mid-2026, broadening the prospects for NTCP-targeted therapies.
  • Future Development Plans: ProQR intends to conduct an investigator-initiated trial in pediatric biliary atresia in China, with initial clinical data anticipated in the first half of 2027, marking a significant step towards addressing unmet medical needs with AX-0810 and AX-0811 in Phase 2 development.
Newsfilter
8.5
06-25Newsfilter
ProQR Therapeutics Completes $50 Million Financing
  • Financing Size: ProQR Therapeutics announced the pricing of 27,624,310 ordinary shares at $1.81 each, expecting gross proceeds of approximately $50 million, indicating strong market demand for its RNA therapies.
  • Strategic Partnership: ProQR has entered into a share purchase agreement with Eli Lilly, allowing Lilly to purchase 5,100,780 shares at the same offering price, thereby maintaining its ownership stake and reinforcing their strategic partnership.
  • Use of Proceeds: The proceeds from this offering will primarily fund research and clinical development of existing and new pipeline candidates, reflecting the company's proactive investment strategy for future product development.
  • Underwriter Lineup: BofA Securities, Evercore ISI, and Cantor are acting as joint lead bookrunning managers for the offering, demonstrating market confidence in ProQR, with the financing expected to close on June 26, 2026.
Wall Street analysts forecast PRQR stock price to rise
3 Analyst Rating
Wall Street analysts forecast PRQR stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
5.00
Averages
8.67
High
12.00
Current: 0.000
sliders
Low
5.00
Averages
8.67
High
12.00
Raymond James
Strong Buy
to
Strong Buy
downgrade
$14 -> $10
AI Analysis
2026-06-26
Reason
Raymond James
Price Target
$14 -> $10
AI Analysis
2026-06-26
downgrade
Strong Buy
to
Strong Buy
Reason
Raymond James lowered the firm's price target on ProQR Therapeutics to $10 from $14 and keeps a Strong Buy rating on the shares. Based on the thesis that early data from the Axiomer RNA editing platform in healthy volunteers may translate into an effective therapy for biliary atresia, the initial Phase 1 dataset and additional key takeaways from ProQR's presentation further support a positive outlook on Axiomer-based candidates in biliary atresia and beyond, the analyst tells investors in a research note.
JonesResearch
Catherine Novack
Buy
downgrade
$11 -> $10
2026-06-26
Reason
JonesResearch
Catherine Novack
Price Target
$11 -> $10
2026-06-26
downgrade
Buy
Reason
JonesResearch analyst Catherine Novack lowered the firm's price target on ProQR Therapeutics to $10 from $11 and keeps a Buy rating on the shares. The firm cites the company's increased share count for the target cut. It sees a buying opportunity on weakness from the topline RNA editing data for AX-0810 in healthy volunteers. The study "hot on all key biomarkers," the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for ProQR Therapeutics NV (PRQR.O) is 0.00, compared to its 5-year average forward P/E of -5.15. For a more detailed relative valuation and DCF analysis to assess ProQR Therapeutics NV's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.15
Current PE
0.00
Overvalued PE
-2.41
Undervalued PE
-7.89

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.53
Current EV/EBITDA
-1.60
Overvalued EV/EBITDA
0.53
Undervalued EV/EBITDA
-3.60

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
40.78
Current PS
14.64
Overvalued PS
149.72
Undervalued PS
-68.16

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Frequently Asked Questions

What is ProQR Therapeutics NV (PRQR) stock price today?

The current price of PRQR is 1.615 USD — it has decreased -2.71

What is ProQR Therapeutics NV (PRQR)'s business?

ProQR Therapeutics N.V. is a biotechnology company based in the Netherlands. The Company is engaged in the discovery and development of ribonucleic Acid (RNA)-based therapeutics for the treatment of severe genetic disorders. Main purpose of the Company is advancement of its Axiomer RNA-editing platform technology. That technology uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unaddressed needs. The Company operates research pipeline that contains of RNA Therapy and AX-0810 Cholestatic Diseases (NTCP).

What is the price predicton of PRQR Stock?

Wall Street analysts forecast PRQR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PRQR is8.67 USD with a low forecast of 5.00 USD and a high forecast of 12.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is ProQR Therapeutics NV (PRQR)'s revenue for the last quarter?

ProQR Therapeutics NV revenue for the last quarter amounts to 2.03M USD, decreased -57.12

What is ProQR Therapeutics NV (PRQR)'s earnings per share (EPS) for the last quarter?

ProQR Therapeutics NV. EPS for the last quarter amounts to -0.13 USD, increased 30.00

How many employees does ProQR Therapeutics NV (PRQR). have?

ProQR Therapeutics NV (PRQR) has 187 emplpoyees as of July 08 2026.

What is ProQR Therapeutics NV (PRQR) market cap?

Today PRQR has the market capitalization of 234.26M USD.