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Intellectia

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High
19.900
Open
19.220
VWAP
18.68
Vol
157.91K
Mkt Cap
975.86M
Low
17.920
Amount
2.95M
EV/EBITDA(TTM)
--
Total Shares
53.53M
EV
1.18B
EV/OCF(TTM)
--
P/S(TTM)
--
Seaport Therapeutics, Inc. is a clinical-stage therapeutics company. The Company is focused on inventing and developing new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders. Its product candidate, GlyphAllo (SPT-300 or Glyph Allopregnanolone), is a novel, Glyphed oral prodrug of allopregnanolone, an endogenous molecule that has been clinically validated in third-party trials for the treatment of postpartum depression. GlyphAgo (SPT-320 or Glyph Agomelatine), is a novel, Glyphed oral prodrug of agomelatine, a clinically validated anxiolytic and antidepressant that is approved for the treatment of generalized anxiety disorder. It is also advancing Glyph2BLS (SPT-348 or Glyph 2-bromo-LSD), a novel, Glyphed oral prodrug of the non-hallucinogenic LSD analog 2-bromo-LSD, in preclinical studies for depressive disorders. GlyphAllo is designed to overcome the bioavailability limitations of allopregnanolone and be durable in MDD.
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Events Timeline

(ET)
2026-05-26
11:10:00
SpaceX Files for IPO Aiming to Raise $80 Billion
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News

NASDAQ.COM
5.0
06-24NASDAQ.COM
Powerlaw CEO Dinsdale Buys $246K in Shares Amid Market Opportunities
  • Executive Purchase: Powerlaw CEO Mike John Dinsdale purchased 15,668 shares of PWRL on Monday at $15.73 each, totaling $246,495, marking his first buy in the past twelve months and indicating confidence in the company's future.
  • Market Opportunity: PWRL shares are currently trading as low as $14.27, which is 9.3% below Dinsdale's purchase price, presenting an attractive entry point for investors and potentially drawing more attention to the stock.
  • Stock Performance: As of Wednesday, Powerlaw's stock is up about 0.5%, reflecting a positive market reaction to Dinsdale's purchase, which may bolster investor confidence in the company's outlook.
  • Seaport Therapeutics Transaction: On the same day, Robert J. Hombach bought 13,000 shares of Seaport Therapeutics for $235,768 at $18.14 each, marking his first purchase in the past twelve months, indicating optimism about the company's prospects.
NASDAQ.COM
9.5
06-09NASDAQ.COM
Seaport Therapeutics Reports Wider Net Loss in Q1 2026
  • Wider Financial Loss: Seaport Therapeutics reported a net loss of $25.41 million for Q1 2026, translating to $10.34 per share, which is a significant increase from last year's loss of $13.13 million or $5.65 per share, indicating ongoing pressures in the market alongside substantial R&D investments.
  • Increased R&D Expenses: The R&D expenses for Q1 2026 reached $21.43 million, up from $10.5 million in the same quarter last year, primarily driven by the advancement of GlyphAllo and GlyphAgo into later stages of development, showcasing the company's commitment to innovation in therapeutics.
  • Strong Cash Position: As of March 31, 2026, Seaport had $212.6 million in cash, cash equivalents, and investments, which is expected to sustain operations through 2029, reflecting robust financial management and strategic planning.
  • Upcoming Milestones: The company anticipates releasing data from the Phase 1 simulation trial of GlyphAllo in the second half of 2026 and expects to present topline data from the BUOY-1 Phase 2b trial for Major Depressive Disorder in the first half of 2027, indicating a proactive approach to clinical development and market readiness.
Newsfilter
9.0
06-09Newsfilter
Seaport Therapeutics Reports Positive Clinical Data for GlyphAgo
  • Clinical Trial Success: Seaport Therapeutics successfully demonstrated favorable safety and tolerability in the multiple-ascending dose (MAD) portion of its Phase 1 trial for GlyphAgo, supporting further development in patients with generalized anxiety disorder (GAD).
  • Dose Selection Support: Seven-day dosing of GlyphAgo achieved therapeutic exposure levels projected to avoid liver enzyme elevations, thereby reducing or eliminating the need for liver function testing, which will aid in dose selection for future clinical trials.
  • Future Trial Plans: Seaport plans to initiate a Phase 2a trial in the second half of 2026 to assess GlyphAgo's potential benefits on sleep in anxiety patients, with topline data expected in early 2028, and a Phase 2b trial is set for the first half of 2027.
  • Platform Advantages: The development of GlyphAgo leverages PureTech's Glyph platform, showcasing its innovative ability to overcome drug metabolism limitations, and is expected to provide new treatment options for GAD patients, addressing a 20-year gap in new drug approvals in this area.
seekingalpha
9.5
06-08seekingalpha
Seaport Therapeutics Reports Q1 Loss and IPO Success
  • Financial Performance: Seaport Therapeutics reported a GAAP EPS of -$10.34 for Q1 2026, indicating ongoing investment in R&D and operations despite financial pressures.
  • Cash Reserves: As of March 31, 2026, the company had $212.6 million in cash, cash equivalents, and investments, which is expected to support its operating plans into 2029, ensuring stability for the coming years.
  • IPO Success: Following March 31, 2026, Seaport completed its IPO, raising gross proceeds of $260 million, providing crucial funding for further development, although underwriting discounts and other expenses will be deducted.
  • Net Loss Comparison: The net loss for Q1 2026 was $25.4 million, compared to a net loss of $13.1 million in Q1 2025, highlighting challenges in financial management and cost control that may affect investor confidence.
Newsfilter
8.5
06-08Newsfilter
Seaport Therapeutics Raises $260 Million in Successful IPO
  • Successful IPO Financing: Seaport Therapeutics completed an upsized IPO in May 2026, raising $260 million in gross proceeds, which will support the company's operations into 2029, reflecting strong market confidence in its neuropsychiatric drug development.
  • Clinical Trial Progress: New data from the Phase 1 trial of GlyphAgoTM indicate that a seven-day dosing regimen can achieve therapeutic exposures at doses projected to avoid liver enzyme elevations, potentially reducing or eliminating the need for liver function testing, thereby enhancing patient safety.
  • New Board Member Appointment: Dr. Sharon Mates has been appointed to Seaport's Board of Directors; she previously served as the Co-Founder and CEO of Intra-Cellular Therapies, bringing extensive industry experience that is expected to drive the company's strategic development in the neuropsychiatry field.
  • Increased R&D Spending: Research and development expenses for Q1 2026 were $21.4 million, significantly up from $10.5 million in Q1 2025, primarily due to accelerated clinical development of GlyphAlloTM and GlyphAgoTM, reflecting the company's ongoing commitment to new drug development.
Yahoo Finance
9.0
06-08Yahoo Finance
GlyphAgo Repeat Dosing Shows Favorable Safety Profile
  • Clinical Trial Results: GlyphAgo demonstrated a favorable safety and tolerability profile in the multiple ascending dose trial with healthy volunteers, with no liver-related adverse events observed, laying a solid foundation for its further development in generalized anxiety disorder patients.
  • Pharmacokinetic Advantages: The seven-day dosing regimen achieved therapeutic exposures of agomelatine that are projected to avoid liver enzyme elevations, thereby reducing or eliminating the need for liver function testing, significantly enhancing clinical applicability.
  • Future Trial Plans: Seaport plans to initiate two parallel Phase 2 clinical trials in the second half of 2026, aimed at validating the efficacy and safety of GlyphAgo for patients with generalized anxiety disorder, potentially providing new treatment options for patients.
  • Enhanced Bioavailability: In crossover trials, GlyphAgo showed a 6.8-fold increase in bioavailability compared to unmodified agomelatine, with 10-fold lower pharmacokinetic variability across different doses, further demonstrating its potential in clinical applications.
Wall Street analysts forecast SPTX stock price to rise
0 Analyst Rating
Wall Street analysts forecast SPTX stock price to rise
0 Buy
0 Hold
0 Sell
Current: 0.000
sliders
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Averages
High
Current: 0.000
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Averages
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Wolfe Research
Rudy Li
Peer Perform
initiated
AI Analysis
2026-07-07
New
Reason
Wolfe Research
Rudy Li
Price Target
AI Analysis
2026-07-07
New
initiated
Peer Perform
Reason
Wolfe Research analyst Rudy Li initiated coverage of Seaport Therapeutics with a Peer Perform rating and no price target. We the firm likes the company's Glyph platform, it expects mixed data from the Phase 2b BUOY-1 study and calls lead asset SPT-300 "a risky bet" in major depressive disorder.
Goldman Sachs
Salveen
initiated
2026-05-26
Reason
Goldman Sachs
Salveen
Price Target
2026-05-26
initiated
Reason
Goldman Sachs analyst Salveen initiated coverage of Seaport Therapeutics with an Early-Stage Biotech rating and no price target. The company is developing oral small molecule therapies in neuropsychiatric disorders, the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for Seaport Therapeutics Inc (SPTX.O) is 0.00, compared to its 5-year average forward P/E of --. For a more detailed relative valuation and DCF analysis to assess Seaport Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
Current PE
0.00
Overvalued PE
Undervalued PE

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
Undervalued EV/EBITDA

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
Current PS
0.00
Overvalued PS
Undervalued PS

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Frequently Asked Questions

What is Seaport Therapeutics Inc (SPTX) stock price today?

The current price of SPTX is 18.23 USD — it has decreased -5.89

What is Seaport Therapeutics Inc (SPTX)'s business?

Seaport Therapeutics, Inc. is a clinical-stage therapeutics company. The Company is focused on inventing and developing new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders. Its product candidate, GlyphAllo (SPT-300 or Glyph Allopregnanolone), is a novel, Glyphed oral prodrug of allopregnanolone, an endogenous molecule that has been clinically validated in third-party trials for the treatment of postpartum depression. GlyphAgo (SPT-320 or Glyph Agomelatine), is a novel, Glyphed oral prodrug of agomelatine, a clinically validated anxiolytic and antidepressant that is approved for the treatment of generalized anxiety disorder. It is also advancing Glyph2BLS (SPT-348 or Glyph 2-bromo-LSD), a novel, Glyphed oral prodrug of the non-hallucinogenic LSD analog 2-bromo-LSD, in preclinical studies for depressive disorders. GlyphAllo is designed to overcome the bioavailability limitations of allopregnanolone and be durable in MDD.

What is the price predicton of SPTX Stock?

Wall Street analysts forecast SPTX stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for SPTX is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Seaport Therapeutics Inc (SPTX)'s revenue for the last quarter?

Seaport Therapeutics Inc revenue for the last quarter amounts to -27.54M USD, increased 70.18

What is Seaport Therapeutics Inc (SPTX)'s earnings per share (EPS) for the last quarter?

Seaport Therapeutics Inc. EPS for the last quarter amounts to -20172000.00 USD, decreased -0.43

How many employees does Seaport Therapeutics Inc (SPTX). have?

Seaport Therapeutics Inc (SPTX) has 58 emplpoyees as of July 08 2026.

What is Seaport Therapeutics Inc (SPTX) market cap?

Today SPTX has the market capitalization of 975.86M USD.