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ZYME Overview

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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
26.830
Open
25.400
VWAP
26.29
Vol
771.62K
Mkt Cap
1.97B
Low
25.310
Amount
20.28M
EV/EBITDA(TTM)
--
Total Shares
73.57M
EV
1.70B
EV/OCF(TTM)
--
P/S(TTM)
23.62
Zymeworks Inc. is a biotechnology company. The Company is engaged in managing a portfolio of healthcare assets and developing a pipeline of multifunctional biotherapeutics to improve the standard of care for conditions, including cancer, inflammation, and autoimmune disease. Its antibody-drug conjugates (ADCs) include ZW191, ZW251, and ZW220. ZW191 is a clinical-stage ADC that targets folate receptor alpha-expressing tumors including ovarian cancer, endometrial cancer, and non-small cell lung cancer (NSCLC), which is built using bystander-active, TOPO1i payload technology, ZD06519. ZW251 is a clinical-stage ADC molecule designed for the treatment of glypican 3 (GPC3)-expressing hepatocellular carcinoma (HCC). ZW220 is an ADC that targets NaPi2b-expressing NSCLC and ovarian cancer, built using bystander active TOPO1i payload technology, ZD06519. Its therapeutic platforms can be used to develop multifunctional fit-for-purpose biotherapeutics with bispecific capabilities.
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Events Timeline

(ET)
2026-06-29
09:30:00
Nasdaq Futures Rise, PetMed Express Stock Soars 32%
select
2026-06-29
06:30:00
Zymeworks to Acquire Theravance Biopharma for $17.00 per Share
select
2026-06-29
06:30:00
Zymeworks to Acquire Theravance Biopharma for $17.00 per Share
select
2026-06-29
06:30:00
Zymeworks to Acquire Theravance Biopharma for $17 per Share
select
2026-06-14 (ET)
2026-06-14
19:30:00
Zymeworks Presents ZW191 Clinical Data at ESMO 2026
select

News

PRnewswire
8.5
07-06PRnewswire
GT Biopharma Integrates AI to Accelerate Drug Development
  • AI Integration: GT Biopharma has integrated AI tools into the discovery and engineering of its tumor-targeting NK cell engagers and multi-domain proteins, with expectations to push multiple new development candidates into pre-IND development by 2027, thereby accelerating clinical timelines and reducing costs.
  • Drug Design Optimization: Utilizing AI-guided sequence and structural analyses, GT Biopharma can prioritize candidates with favorable binding, stability, and developability profiles, aiming to eliminate potential failures early in the discovery phase, thus minimizing costly fixes later in development.
  • Clinical Trial Progress: Currently, GT Biopharma's lead program GTB-3650 is in a Phase 1 trial for CD33-expressing blood cancers, while its second candidate GTB-5550 began dosing for B7-H3-expressing solid tumors in May 2026, indicating positive momentum in clinical development.
  • Future Development Potential: GT Biopharma plans to leverage its AI-enabled discovery engine to replenish its pipeline behind existing projects, targeting multiple new candidates for clinical development by 2027, thereby enhancing its competitive position in the rapidly evolving biopharmaceutical market.
stocktwits
8.5
06-29stocktwits
Theravance Biopharma Acquired by Zymeworks for $17.00 per Share
  • Deal Overview: Zymeworks is acquiring Theravance Biopharma for $17.00 per share in cash, totaling an equity value of $929 million, which represents a 22% premium over the stock's closing price on March 3, 2026, indicating recognition of Theravance's future potential.
  • Future Earnings Rights: Theravance shareholders will receive a contingent value right entitling them to 80% of net proceeds related to ampreloxetine over the next ten years, providing additional revenue opportunities for shareholders while enhancing Zymeworks' strategic value.
  • Clinical Trial Impact: The topline results of Theravance's CYPRESS phase 3 study, announced on March 3, did not meet its primary endpoint, leading to the decision to wrap up the ampreloxetine program, which may affect the company's future R&D direction and market performance.
  • Market Reaction: Following the acquisition announcement, Theravance's stock was down over 2.5% in premarket trading, reflecting cautious market sentiment towards the deal and indicating investor uncertainty regarding the company's future prospects.
seekingalpha
8.5
06-29seekingalpha
Zymeworks Acquires Theravance Biopharma for $929M
  • Acquisition Overview: Zymeworks announced its acquisition of Theravance Biopharma in an all-cash deal valued at approximately $929 million, paying $17 per share, aimed at expanding its commercial portfolio with the COPD treatment YUPELRI.
  • Financial Impact Analysis: YUPELRI currently generates about $60 million in annual cash flow, and the acquisition includes additional royalty interests, milestone payments, and approximately $2.5 billion in Irish tax attributes, which are expected to significantly enhance Zymeworks' financial position.
  • Financing Structure: The deal will be financed primarily through a $350 million non-recourse note from OMERS Life Sciences, Theravance's expected $360 million net cash balance at closing, and $219 million of Zymeworks' cash, showcasing a diverse financing strategy.
  • Approval and Expectations: The boards of both companies have unanimously approved the transaction, which is expected to close in the second half of 2026; however, TBPH stock dropped 3% in pre-market trading on Monday, indicating some market skepticism despite the deal's long-term strategic significance.
Newsfilter
8.5
06-29Newsfilter
Zymeworks Acquires Theravance Biopharma for $929 Million
  • Acquisition Overview: Zymeworks is acquiring Theravance Biopharma for $17 per share, totaling approximately $929 million, with the transaction expected to close in the second half of 2026, significantly enhancing Zymeworks' product portfolio and revenue sources.
  • Cash Flow Expectations: The acquisition of YUPELRI® is projected to generate around $60 million in annual cash flow for Zymeworks, alongside existing cash flows from Ziihera®, supporting ongoing investments in R&D and shareholder returns.
  • Innovative Financing Structure: The acquisition is primarily financed through a $350 million non-recourse note, minimizing Zymeworks' capital risk while preserving financial flexibility, with an expected reduction of approximately 50% in net investment.
  • Strategic Development Direction: Zymeworks plans to optimize its R&D and commercialization strategies by integrating Theravance Biopharma's assets, further driving long-term shareholder value creation, particularly in response to the growing market demand for COPD treatments.
PRnewswire
7.5
06-18PRnewswire
Gandeeva and Zymeworks Partner to Enhance Antibody Drug Discovery
  • Partnership Background: Vancouver-based Gandeeva Therapeutics has partnered with Zymeworks to utilize cryo-electron microscopy (cryo-EM) for generating high-resolution structural data of antibody-antigen interfaces, thereby enhancing antibody drug discovery and development.
  • Technical Breakthrough: Gandeeva scientists successfully determined the structure of a small and flexible antigen (<20 kDa) bound to a Fab fragment of an antibody developed by Zymeworks, visualizing the nine amino acids forming the antibody-binding epitope at a resolution of 2.6 Å, significantly improving the understanding of complex biological targets.
  • Business Impact: Zymeworks' Chief Scientific Officer, Paul Moore, stated that knowledge of precise interactions at these challenging targets is crucial for selecting antibody leads and provides essential insights for optimizing biologics, potentially accelerating their drug development processes.
  • Strategic Significance: Gandeeva's founder, Sriram Subramaniam, emphasized that obtaining near-atomic resolution cryo-EM structures is a game-changer, particularly in the context of accelerating AI-driven antibody design, as it offers rapid feedback for testing and validating antibodies, thereby enhancing overall R&D efficiency.
Newsfilter
9.0
06-14Newsfilter
ZW191 Shows Significant Anti-Tumor Activity in Platinum-Resistant Ovarian Cancer Patients
  • Clinical Data Highlights: ZW191 demonstrated a confirmed objective response rate (cORR) of 78.6% in platinum-resistant ovarian cancer patients, particularly excelling in FRα-positive individuals, indicating its potential to transform treatment paradigms for difficult-to-treat cancers.
  • Survival Data: The median progression-free survival across all dose levels was reported at 7.6 months, suggesting a positive impact on extending patient survival, which further underscores the necessity for its clinical development.
  • Tolerability Analysis: While 98% of patients experienced treatment-emergent adverse events (TEAEs), most were manageable, with 55% reporting grade 3 or higher events, indicating that ZW191's safety profile aligns with its promising clinical application.
  • Dose Optimization Study Completion: The dose optimization phase of ZW191 has completed patient recruitment, with future development expected to inform dose selection between 6.4 mg/kg and 9.6 mg/kg, signaling a broad potential for clinical application.
Wall Street analysts forecast ZYME stock price to rise
14 Analyst Rating
Wall Street analysts forecast ZYME stock price to rise
14 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
30.00
Averages
35.55
High
42.00
Current: 0.000
sliders
Low
30.00
Averages
35.55
High
42.00
Truist
Buy
maintain
$28 -> $31
AI Analysis
2026-07-07
New
Reason
Truist
Price Target
$28 -> $31
AI Analysis
2026-07-07
New
maintain
Buy
Reason
Truist raised the firm's price target on Zymeworks to $31 from $28 and keeps a Buy rating on the shares as part of a broader research note updating the firm's models and previewing Q2 earnings in Biotech. The firm is anticipating a rebound from a traditionally softer start to the year, with strength in Q2 prints for commercial franchises within its coverage, the analyst tells investors in a research note. Truist adds that it sees a robust catalyst calendar, supported by sector optimism and deal activity, as drivers for the recent momentum across the sector.
Wells Fargo
Overweight
maintain
$34 -> $37
2026-06-30
Reason
Wells Fargo
Price Target
$34 -> $37
2026-06-30
maintain
Overweight
Reason
Wells Fargo raised the firm's price target on Zymeworks to $37 from $34 and keeps an Overweight rating on the shares. The firm views the acquisition of Theravance Biopharma as setting the tone for future royalty portfolio buildout. Further, Wells thinks the multi-component structure of this deal looks appropriate for a company with internal development capabilities.
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Valuation Metrics

The current forward P/E ratio for Zymeworks Inc (ZYME.O) is 26.32, compared to its 5-year average forward P/E of -2.68. For a more detailed relative valuation and DCF analysis to assess Zymeworks Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.68
Current PE
26.32
Overvalued PE
17.49
Undervalued PE
-22.84

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
6.70
Current EV/EBITDA
-0.45
Overvalued EV/EBITDA
46.85
Undervalued EV/EBITDA
-33.45

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
11.34
Current PS
9.95
Overvalued PS
25.09
Undervalued PS
-2.40

Financials

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Whales Holding ZYME

B
BVF Partners L.P.
Holding
ZYME
+23.36%
3M Return
R
Redmile Group, LLC
Holding
ZYME
+22.75%
3M Return
E
EcoR1 Capital, LLC
Holding
ZYME
+20.86%
3M Return
V
Vestal Point Capital, LP
Holding
ZYME
+11.31%
3M Return
R
Rubric Capital Management LP
Holding
ZYME
+8.04%
3M Return

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Frequently Asked Questions

What is Zymeworks Inc (ZYME) stock price today?

The current price of ZYME is 26.72 USD — it has increased 5.49

What is Zymeworks Inc (ZYME)'s business?

Zymeworks Inc. is a biotechnology company. The Company is engaged in managing a portfolio of healthcare assets and developing a pipeline of multifunctional biotherapeutics to improve the standard of care for conditions, including cancer, inflammation, and autoimmune disease. Its antibody-drug conjugates (ADCs) include ZW191, ZW251, and ZW220. ZW191 is a clinical-stage ADC that targets folate receptor alpha-expressing tumors including ovarian cancer, endometrial cancer, and non-small cell lung cancer (NSCLC), which is built using bystander-active, TOPO1i payload technology, ZD06519. ZW251 is a clinical-stage ADC molecule designed for the treatment of glypican 3 (GPC3)-expressing hepatocellular carcinoma (HCC). ZW220 is an ADC that targets NaPi2b-expressing NSCLC and ovarian cancer, built using bystander active TOPO1i payload technology, ZD06519. Its therapeutic platforms can be used to develop multifunctional fit-for-purpose biotherapeutics with bispecific capabilities.

What is the price predicton of ZYME Stock?

Wall Street analysts forecast ZYME stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZYME is35.55 USD with a low forecast of 30.00 USD and a high forecast of 42.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zymeworks Inc (ZYME)'s revenue for the last quarter?

Zymeworks Inc revenue for the last quarter amounts to 2.41M USD, decreased -91.12

What is Zymeworks Inc (ZYME)'s earnings per share (EPS) for the last quarter?

Zymeworks Inc. EPS for the last quarter amounts to -0.59 USD, increased 96.67

How many employees does Zymeworks Inc (ZYME). have?

Zymeworks Inc (ZYME) has 264 emplpoyees as of July 08 2026.

What is Zymeworks Inc (ZYME) market cap?

Today ZYME has the market capitalization of 1.97B USD.