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ALNY Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

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High
319.855
Open
318.010
VWAP
318.21
Vol
193.11K
Mkt Cap
41.79B
Low
315.415
Amount
61.45M
EV/EBITDA(TTM)
51.38
Total Shares
133.51M
EV
41.46B
EV/OCF(TTM)
58.15
P/S(TTM)
9.90
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
Show More

Events Timeline

(ET)
2026-06-25
09:30:00
Komodo Health Expands Strategic Partnership with Alnylam Pharmaceuticals
select
2026-06-03 (ET)
2026-06-03
16:50:00
Alnylam and Inceptive Sign Up to $2B Strategic Collaboration Agreement
select
2026-05-12 (ET)
2026-05-12
05:50:00
Alnylam Releases New Analyses Supporting Vutrisiran for Cardiac Amyloidosis Treatment
select
2026-05-07 (ET)
2026-05-07
09:40:00
MBX Biosciences Appoints Mark Soued as Chief Commercial Officer
select

News

Fool
9.5
07-02Fool
Alnylam Pharmaceuticals Shares Drop 24%, Yet Optimism Persists
  • Significant Revenue Growth: Alnylam Pharmaceuticals reported a 121% year-over-year surge in product revenue to $1.04 billion in Q1, primarily driven by a 153% increase in its ATTR franchise, indicating strong market demand in the rare disease treatment sector.
  • Profitability Improvement: The company achieved earnings per share (EPS) of $1.51, a substantial turnaround from a loss of $0.14 per share in the same period last year, demonstrating Alnylam's rapid transition into a profitable commercial powerhouse, which boosts investor confidence.
  • Expansion into New Indications: New data for Alnylam's Amvuttra reinforces its position as a first-line treatment for cardiomyopathy, setting the stage for a massive commercial launch and further market share expansion.
  • Strong Technological Moat: Alnylam's RNA interference platform creates a deep technological moat, and its collaboration with Inceptive Nucleics on AI accelerates the discovery of next-generation RNAi structures, ensuring its competitive edge in the biotech industry.
NASDAQ.COM
9.5
07-02NASDAQ.COM
Alnylam Pharmaceuticals Reports Strong Q1 Performance
  • Significant Revenue Growth: Alnylam Pharmaceuticals reported a 121% year-over-year surge in product revenue to $1.04 billion in Q1, primarily driven by a 153% increase in its transthyretin amyloidosis (ATTR) franchise, indicating strong market demand in the rare disease treatment sector.
  • Profitability Improvement: The company achieved earnings per share (EPS) of $1.51, a substantial turnaround from a loss of $0.14 per share in the same period last year, marking a significant improvement in profitability and showcasing its transition from a high-burn clinical biotech to a profitable commercial powerhouse.
  • Broad Market Outlook: Alnylam's guidance for full-year 2026 net product revenue ranges between $4.9 billion and $5.3 billion, reflecting a 71% year-over-year growth at the midpoint, highlighting the company's potential to penetrate mainstream high-volume therapeutic markets, particularly in cardiomyopathy and hypertension.
  • Strong Technological Moat: Alnylam's RNA interference (RNAi) drug delivery system creates a deep technological moat, and its strategic AI collaboration with Inceptive Nucleics accelerates the discovery of next-generation RNAi structures, ensuring the company's competitive edge in the rapidly evolving biotech landscape.
Newsfilter
7.5
06-25Newsfilter
Komodo Expands Partnership with Alnylam to Enhance AI Decision-Making
  • Partnership Expansion: Komodo Health has expanded its strategic partnership with Alnylam Pharmaceuticals to scale the Marmot analytics platform across key enterprise functions, enhancing AI-driven decision-making and improving overall operational efficiency.
  • Real-Time Intelligence Transformation: The Marmot platform, built on the Healthcare Map, integrates over 330 million de-identified patient journeys, enabling Alnylam to break free from fragmented analytics and achieve real-time, transparent healthcare intelligence, significantly reducing reporting cycles from months to hours.
  • New Feature Launch: Komodo has released new capabilities for Marmot aimed at making healthcare intelligence accessible to all users, ensuring that every analysis is reproducible and verifiable, thereby enhancing the scientific rigor and accuracy of decision-making while embedding AI into core enterprise processes.
  • Industry Transformation Trend: This partnership reflects a broader shift in healthcare and life sciences, as organizations move beyond mere AI experimentation to adopt new operating models centered around real-time intelligence, addressing increasingly complex market demands.
seekingalpha
9.0
06-23seekingalpha
Regeneron's Cemdisiran Marketing Applications Accepted by U.S. and European Regulators
  • Drug Application Progress: Regeneron (REGN) and Alnylam Pharmaceuticals (ALNY) have had their marketing applications for the experimental therapy cemdisiran accepted by U.S. and European regulators, marking a significant advancement in treating myasthenia gravis.
  • Priority Review Approval: The U.S. FDA has issued a priority review for cemdisiran's New Drug Application with a target action date in November, which will expedite the drug's market entry and is expected to significantly enhance Regeneron's competitive position.
  • European Market Outlook: The European Medicines Agency has accepted the marketing authorization application for cemdisiran, with final approval from the European Commission anticipated in H2 2027, laying the groundwork for Regeneron's expansion in the European market.
  • Clinical Trial Results: Based on 24-week data, Regeneron announced in August that the treatment arm testing cemdisiran as a single agent in adults with symptomatic myasthenia gravis met the primary goals of the NIMBLE trial, further validating the drug's efficacy and safety.
NASDAQ.COM
5.0
06-23NASDAQ.COM
Dyne Therapeutics Appoints Barry Greene to Board of Directors
  • New Board Appointment: Dyne Therapeutics has appointed Barry Greene to its Board of Directors, bringing over 30 years of biopharmaceutical experience focused on the development and commercialization of therapies for rare diseases, neuroscience, and oncology, which is expected to provide strategic guidance for the company.
  • Rich Leadership Experience: Greene currently serves as the lead independent director at Karyopharm Therapeutics and has been on the Board since 2013, and his extensive leadership experience will aid Dyne in navigating the complex biopharmaceutical market.
  • Former CEO Background: Greene previously held the position of CEO at Sage Therapeutics from December 2020 to July 2025, and his expertise in drug development and commercialization will support Dyne's future growth initiatives.
  • Positive Stock Performance: Dyne shares closed at $20.87 on Monday, reflecting a 5.40% increase, indicating a positive market reaction to the new appointment, which may enhance investor confidence and drive future growth.
Newsfilter
8.5
06-12Newsfilter
Alnylam to Host 10th RNAi Roundtable Series
  • RNAi Roundtable Series: Alnylam Pharmaceuticals announced its plan to host the 10th series of 'RNAi Roundtable' webinars in the coming months, featuring presentations from scientists and medical experts discussing recent advancements in the company's pipeline programs to address unmet clinical needs.
  • Live Webcast Arrangement: Each event will be webcast live on the company's investor website, with replays available approximately three hours after each session, ensuring timely access to critical information for investors.
  • 2030 Strategic Goals: Alnylam aims to increase its clinical programs from over 25 to more than 40 by 2030, demonstrating its commitment to sustainable innovation and market expansion in the RNAi therapeutics sector.
  • Increased R&D Investment: The company is significantly ramping up its R&D investments to extend the application of RNAi technology, aiming to deliver multiple new transformative medicines for patients with serious diseases, thereby reinforcing its market leadership position.
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$510 -> $470
AI Analysis
2026-06-29
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$510 -> $470
AI Analysis
2026-06-29
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Alnylam to $470 from $510 and keeps a Buy rating on the shares. The firm reduced its near-term estimates for Amvuttra but continues to estimate Alnylam's TTR franchise growing to over $20B in annual revenues by 2040.
Citi
NULL
to
Buy
initiated
$380
2026-05-18
Reason
Citi
Price Target
$380
2026-05-18
initiated
NULL
to
Buy
Reason
Citi initiated coverage of Alnylam with a Buy rating and $380 price target. The expanded launch of Amvuttra for ATTR-CM has \"no doubt been impressive,\" says the analyst, who views 28% year-to-date pullback as \"an attractive long-term entry point.\" Pressure has been led by competitor concerns, but the firm sees \"more tailwinds than headwinds for Amvuttra,\" the analyst added.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALNY
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Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals Inc (ALNY.O) is 34.13, compared to its 5-year average forward P/E of -36.90. For a more detailed relative valuation and DCF analysis to assess Alnylam Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-36.90
Current PE
34.13
Overvalued PE
38.64
Undervalued PE
-112.44

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7401.29
Current EV/EBITDA
23.84
Overvalued EV/EBITDA
51041.60
Undervalued EV/EBITDA
-65844.17

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
13.89
Current PS
5.73
Overvalued PS
18.37
Undervalued PS
9.41

Financials

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Whales Holding ALNY

B
Bluebox Asset Management Uk Ltd.
Holding
ALNY
+48.50%
3M Return
D
Deerfield Management Company, L.P.
Holding
ALNY
+18.60%
3M Return
B
Bellevue Asset Management AG
Holding
ALNY
+18.31%
3M Return
J
Jacobs Levy Equity Management Inc
Holding
ALNY
+12.72%
3M Return
V
Voleon Capital Management LP
Holding
ALNY
+12.42%
3M Return
L
Lombard Odier Asset Management (Switzerland) SA
Holding
ALNY
+12.38%
3M Return

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Frequently Asked Questions

What is Alnylam Pharmaceuticals Inc (ALNY) stock price today?

The current price of ALNY is 319.35 USD — it has increased 2.02

What is Alnylam Pharmaceuticals Inc (ALNY)'s business?

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

What is the price predicton of ALNY Stock?

Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is479.53 USD with a low forecast of 351.00 USD and a high forecast of 580.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alnylam Pharmaceuticals Inc (ALNY)'s revenue for the last quarter?

Alnylam Pharmaceuticals Inc revenue for the last quarter amounts to 1.17B USD, increased 96.43

What is Alnylam Pharmaceuticals Inc (ALNY)'s earnings per share (EPS) for the last quarter?

Alnylam Pharmaceuticals Inc. EPS for the last quarter amounts to 1.51 USD, decreased -1178.57

How many employees does Alnylam Pharmaceuticals Inc (ALNY). have?

Alnylam Pharmaceuticals Inc (ALNY) has 2500 emplpoyees as of July 07 2026.

What is Alnylam Pharmaceuticals Inc (ALNY) market cap?

Today ALNY has the market capitalization of 41.79B USD.