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ZVRA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
14.570
Open
13.990
VWAP
14.20
Vol
1.88M
Mkt Cap
853.62M
Low
13.580
Amount
26.63M
EV/EBITDA(TTM)
11.15
Total Shares
59.12M
EV
625.22M
EV/OCF(TTM)
48.98
P/S(TTM)
6.60
Zevra Therapeutics, Inc. is a commercial-stage rare disease company with a late-stage pipeline committed to bringing therapeutics to people living with rare diseases. Its commercial products and active development assets are MIPLYFFA, Arimoclomol, OLPRUVA, and Celiprolol. Its lead product, Niemann-Pick disease type C (NPC), is a rare, progressive neurodegenerative disorder. NPC is an ultra-rare and progressive neurodegenerative disease characterized by an inability of the body to transport cholesterol and lipids inside of cells. OLPRUVA (sodium phenylbutyrate) for oral suspension is approved in the United States as adjunctive therapy to standard of care, which includes dietary management, for the chronic management of UCDs involving deficiencies of carbamylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase. Celiprolol is a selective adrenoceptor modulator (SAM). Celiprolol is approved in certain EU states for the treatment of hypertension and angina.
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Events Timeline

(ET)
2026-06-23
08:00:00
Zevra Therapeutics Publishes Arimoclomol Study Results in Niemann-Pick Disease Children
select
2026-06-11 (ET)
2026-06-11
09:30:00
Zevra Therapeutics Chief Medical Officer Resigns
select

News

NASDAQ.COM
9.0
06-24NASDAQ.COM
Zevra Publishes Encouraging Phase 2/3 Data for MIPLYFFA in Niemann-Pick Disease
  • Clinical Trial Results: Zevra Therapeutics announced encouraging Phase 2/3 data for MIPLYFFA in treating Niemann-Pick type C disease in pediatric patients under two years old, indicating good safety and potential therapeutic effects, which may offer new hope for patients with this rare disease.
  • Drug Mechanism: MIPLYFFA (arimoclomol) activates E3 and EB transcription factors to upregulate CLEAR genes, facilitating the removal of unesterified cholesterols from fibroblast lysosomes, thereby halting disease progression and highlighting its significance in treating metabolic disorders.
  • Regulatory Progress: Zevra has filed a Marketing Authorization Application (MAA) with the European Medicines Agency to clear arimoclomol as a treatment for Niemann-Pick disease, and approval would further enhance the company's market position in the rare disease sector.
  • Market Reaction: ZVRA's stock closed up 2.77% at $13 on Tuesday, although it dipped 0.54% to $12.93 in after-hours trading, reflecting a positive investor response to the clinical data while maintaining cautious sentiment regarding future regulatory outcomes.
Newsfilter
9.0
06-23Newsfilter
Zevra Publishes Arimoclomol Study Results in Infants
  • Clinical Study Results: Zevra Therapeutics announced the publication of results from a phase 2/3 open-label study evaluating arimoclomol in infants aged 12 to 24 months with Niemann-Pick disease type C, demonstrating good safety and tolerability while pharmacokinetic results align with older pediatric populations, indicating potential for earlier treatment initiation.
  • Drug Approval Background: Arimoclomol was approved by the FDA in September 2024 for the treatment of Niemann-Pick disease type C, showing its ability to enhance the activation of transcription factors EB and E3, leading to the upregulation of CLEAR genes, which suggests long-term clinical benefits for patients.
  • Market Potential: Zevra's MIPLYFFA has been tested in over 270 patients globally, providing more than five years of patient experience, showcasing the drug's broad applicability in treating Niemann-Pick disease type C, particularly in pediatric patients.
  • Regulatory Application Progress: Zevra has submitted a Marketing Authorization Application to the European Medicines Agency for arimoclomol, aiming to expand its market share in the treatment of Niemann-Pick disease type C, reflecting the company's ongoing investment and commitment to this field.
stocktwits
6.0
06-09stocktwits
Zevra Therapeutics Price Target Raised to $25 Amid Positive Analyst Sentiment
  • Analyst Price Target Increase: Citizens raised Zevra Therapeutics' price target from $18 to $25 while maintaining an 'Outperform' rating, reflecting optimism regarding the extended market exclusivity of Miplyffa, which is expected to further boost investor confidence.
  • Strong Market Performance: Shares of Zevra Therapeutics jumped 8% on Tuesday, reaching their highest level in nearly five years, as investors reacted strongly to favorable analyst commentary linked to recent patent developments, indicating enhanced market confidence in the company's long-term prospects.
  • Miplyffa Sales Surge: In 2025, Miplyffa generated $87.4 million in revenue, accounting for over 80% of Zevra's total sales, marking a significant increase from $10.1 million the previous year, underscoring the drug's importance and market demand in treating rare neurological disorders.
  • Investor Sentiment Shift: Retail sentiment surrounding ZVRA on Stocktwits shifted from 'neutral' to 'extremely bullish,' with message volumes surging nearly 1,200% over the past 24 hours, reflecting strong optimism about the stock's future performance.
NASDAQ.COM
8.5
06-09NASDAQ.COM
Tango Therapeutics Shares Surge Over 50% on Positive Trial Data
  • Positive Clinical Trial Data: Tango Therapeutics' Vopimetostat shows a 90% six-month progression-free survival rate in its Phase 1/2 trial for pancreatic cancer, prompting plans to advance to Phase 3, thereby enhancing its competitive edge in cancer treatment.
  • Aspire Biopharma Growth Prospects: Aspire Biopharma aims to file its NDA for high-dose sublingual aspirin by the end of 2026, and its acquisition of Dura Driver Control Systems is expected to generate over $200 million in revenue, further solidifying its market position.
  • Alvotech FDA Application Progress: Alvotech's AVT16 biosimilar application has been accepted for FDA review, which is anticipated to significantly bolster its competitive stance in the biopharmaceutical market, particularly for treating Crohn's disease and ulcerative colitis.
  • Zevra Patent Protection Enhancement: Zevra Therapeutics' MIPLYFFA has been listed in the Orange Book by the U.S. Patent Office, with patent protection extending to 2041, expected to significantly enhance its exclusivity and revenue potential in the rare disease market.
stocktwits
2.0
06-08stocktwits
Zevra's Patent Protection Extended to 2041 for MIPLYFFA
  • Enhanced Patent Protection: Zevra Therapeutics announced that the new patent for its only FDA-approved drug, MIPLYFFA, will protect its market position until 2041, blocking cheaper generic alternatives and significantly boosting investor confidence while ensuring stable future cash flows.
  • Significant Revenue Growth: In 2025, MIPLYFFA generated $87.4 million in net revenue, a substantial increase from $10.1 million in 2024, accounting for 82% of the company's total net revenue, indicating that the drug's strong market performance has propelled Zevra from a net loss to profitability.
  • Analyst Outlook Positive: Cantor Fitzgerald analyst Kristen Kluska raised Zevra's price target from $24 to $34 while maintaining an 'Overweight' rating, citing the new patent's
Newsfilter
8.5
06-08Newsfilter
Zevra Submits MIPLYFFA Patent for Orange Book Listing
  • Enhanced Patent Protection: Zevra Therapeutics has submitted a patent application for MIPLYFFA® (arimoclomol) with a validity extending to 2041, further strengthening its intellectual property protection and ensuring competitive advantage in the future market.
  • Addressing Unmet Needs: MIPLYFFA represents a crucial therapeutic option for patients with Niemann-Pick disease type C (NPC), an ultra-rare and progressive neurodegenerative disease, highlighting the company's commitment to addressing patient needs.
  • Market Access Strategy: By listing the patent in the FDA's Orange Book, Zevra aims to clarify the market exclusivity of its branded drug, thereby delaying the entry of generic competitors, protecting its market share, and enhancing long-term value.
  • Patent Term Extension Application: The company has also applied for an extension of another patent set to expire in 2029, currently awaiting a determination from the U.S. Patent and Trademark Office, demonstrating its proactive strategy in intellectual property management.
Wall Street analysts forecast ZVRA stock price to rise
6 Analyst Rating
Wall Street analysts forecast ZVRA stock price to rise
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
21.00
Averages
24.00
High
26.00
Current: 0.000
sliders
Low
21.00
Averages
24.00
High
26.00
Guggenheim
Eddie Hickman
Buy
maintain
$23 -> $25
AI Analysis
2026-05-08
Reason
Guggenheim
Eddie Hickman
Price Target
$23 -> $25
AI Analysis
2026-05-08
maintain
Buy
Reason
Guggenheim analyst Eddie Hickman raised the firm's price target on Zevra Therapeutics to $25 from $23 and keeps a Buy rating on the shares. The firm expects growth to continue as the GeneDx program drives new diagnoses, the European opportunity crystallizes, and patient retention remains high, the analyst tells investors in a post-Q1 note.
BTIG
Kambiz Yazdi
Buy
initiated
$23
2026-03-16
Reason
BTIG
Kambiz Yazdi
Price Target
$23
2026-03-16
initiated
Buy
Reason
BTIG analyst Kambiz Yazdi initiated coverage of Zevra Therapeutics with a Buy rating and $23 price target. Zevra's current valuation appears to reflect conservative adoption of Miplyffa limited to the existing U.S. diagnosed NPC population, establishing a downside floor based on that cohort, the analyst tells investors in a research note. Upside catalysts in 2026 include expansion of newly diagnosed U.S. patients, potential EU approval, patent term extension to lengthen exclusivity, and optionality from accelerating celiprolol development in VEDS, the firm says.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ZVRA
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Valuation Metrics

The current forward P/E ratio for Zevra Therapeutics Inc (ZVRA.O) is 13.07, compared to its 5-year average forward P/E of 0.91. For a more detailed relative valuation and DCF analysis to assess Zevra Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
0.91
Current PE
13.07
Overvalued PE
30.18
Undervalued PE
-28.36

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-5.77
Current EV/EBITDA
15.49
Overvalued EV/EBITDA
11.07
Undervalued EV/EBITDA
-22.60

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
9.01
Current PS
4.53
Overvalued PS
16.60
Undervalued PS
1.43

Financials

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Whales Holding ZVRA

N
Nantahala Capital Management, LLC
Holding
ZVRA
+13.98%
3M Return

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Frequently Asked Questions

What is Zevra Therapeutics Inc (ZVRA) stock price today?

The current price of ZVRA is 14.44 USD — it has increased 3.36

What is Zevra Therapeutics Inc (ZVRA)'s business?

Zevra Therapeutics, Inc. is a commercial-stage rare disease company with a late-stage pipeline committed to bringing therapeutics to people living with rare diseases. Its commercial products and active development assets are MIPLYFFA, Arimoclomol, OLPRUVA, and Celiprolol. Its lead product, Niemann-Pick disease type C (NPC), is a rare, progressive neurodegenerative disorder. NPC is an ultra-rare and progressive neurodegenerative disease characterized by an inability of the body to transport cholesterol and lipids inside of cells. OLPRUVA (sodium phenylbutyrate) for oral suspension is approved in the United States as adjunctive therapy to standard of care, which includes dietary management, for the chronic management of UCDs involving deficiencies of carbamylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase. Celiprolol is a selective adrenoceptor modulator (SAM). Celiprolol is approved in certain EU states for the treatment of hypertension and angina.

What is the price predicton of ZVRA Stock?

Wall Street analysts forecast ZVRA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZVRA is24.00 USD with a low forecast of 21.00 USD and a high forecast of 26.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zevra Therapeutics Inc (ZVRA)'s revenue for the last quarter?

Zevra Therapeutics Inc revenue for the last quarter amounts to 36.22M USD, increased 77.54

What is Zevra Therapeutics Inc (ZVRA)'s earnings per share (EPS) for the last quarter?

Zevra Therapeutics Inc. EPS for the last quarter amounts to 0.63 USD, decreased -1150.00

How many employees does Zevra Therapeutics Inc (ZVRA). have?

Zevra Therapeutics Inc (ZVRA) has 61 emplpoyees as of July 08 2026.

What is Zevra Therapeutics Inc (ZVRA) market cap?

Today ZVRA has the market capitalization of 853.62M USD.