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CGTX Overview

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ET
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ET
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Intellectia

Loading chart...

High
1.125
Open
1.050
VWAP
1.07
Vol
1.95M
Mkt Cap
96.66M
Low
1.010
Amount
2.09M
EV/EBITDA(TTM)
--
Total Shares
89.50M
EV
64.63M
EV/OCF(TTM)
--
P/S(TTM)
--
Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. The Company is investigating its lead candidate, zervimesine (CT1812), in clinical programs in dementia with Lewy bodies (DLB) and Alzheimer’s disease. Its CT1812 and pipeline of sigma-2 modulators can regulate pathways that are impaired in these diseases for the treatment of degenerative diseases. Its lead product candidate, CT1812, is an orally delivered, small molecule designed to protect neuronal synapses by preventing the binding of oligomers of pathogenic proteins. Its pipeline candidates were discovered using proprietary biology and chemistry platforms designed to identify novel drug targets and disease-modifying therapies that address dysregulated pathways. It is developing other product candidates in the area of synucleinopathies.
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Events Timeline

(ET)
2026-06-24
08:00:00
Cognition Therapeutics Aligns with FDA, Plans Key Trial to Start in 2027
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2026-06-16 (ET)
2026-06-16
08:00:00
Cognition Therapeutics Receives Patent Allowance Valid Until 2050
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2026-05-21 (ET)
2026-05-21
07:50:00
Cognition Therapeutics Meets with FDA to Discuss Zervimesine
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2026-05-07 (ET)
2026-05-07
18:30:00
Cognition Schedules Meeting with FDA for May 20, 2026
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2026-03-17 (ET)
2026-03-17
07:50:00
Cognition Therapeutics Study Shows Zervimesine Slows DLB Progression
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2026-03-02 (ET)
2026-03-02
07:40:00
Cognition Therapeutics Advances Zervimesine Development
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2026-01-27 (ET)
2026-01-27
07:40:00
Cognition Therapeutics Holds Meeting with FDA to Discuss Zervimesine
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2026-01-06 (ET)
2026-01-06
07:40:00
Cognition Therapeutics Publishes Zervimesine Study Results
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2025-12-18 (ET)
2025-12-18
16:20:00
Cognition Therapeutics Files $300M Mixed Securities Shelf
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News

stocktwits
9.0
06-24stocktwits
CGTX Shares Plunge 33% Amid Regulatory Concerns
  • Trial Progress: CGTX plans to initiate a Phase 3 trial for Zervimesine targeting DLB psychosis in mid-2027, with the FDA providing favorable feedback on key aspects of the study, potentially supporting the company's future development.
  • Drug Efficacy Analysis: In the Phase 2 Shimmer study, Zervimesine demonstrated significant efficacy in improving psychosis symptoms in mild-to-moderate DLB patients, with data showing an 89% reduction in the progression of hallucinations and delusions, laying a strong foundation for further research.
  • Market Reaction: CGTX shares plummeted over 33% on Wednesday, marking the largest single-day drop in nearly two years, as investors expressed concerns about the company's Phase 3 program's prospects following a recent regulatory update, leading to a cautious market sentiment.
  • Financial Position Analysis: As of March 31, 2026, CGTX reported approximately $31.2 million in cash and cash equivalents, which is expected to fund operations and capital expenditures through the second quarter of 2027; however, investor concerns about potential dilution remain prevalent.
NASDAQ.COM
9.0
06-24NASDAQ.COM
Cognition Therapeutics Achieves Key FDA Alignment for Zervimesine Study
  • Key FDA Alignment: Cognition Therapeutics has reached a significant agreement with the U.S. FDA regarding the design of its pivotal Phase 3 study for Zervimesine targeting psychosis associated with dementia with Lewy bodies (DLB), marking a major regulatory milestone in a field lacking approved treatments.
  • Trial Design Details: The planned trial will enroll DLB patients experiencing hallucinations and delusions, with randomization to either 100 mg of Zervimesine or placebo daily for nine months, utilizing the Neuropsychiatric Inventory as a primary endpoint.
  • Clinical Data Foundation: The Phase 3 design builds on Phase 2 SHIMMER study results, which demonstrated that Zervimesine significantly improved psychosis symptoms compared to placebo, with a recent analysis indicating an 89% reduction in the progression of hallucinations and delusions.
  • Urgent Market Need: Up to 80% of DLB patients experience psychosis, and there are currently no FDA-approved treatments available, highlighting the critical unmet medical need that Cognition Therapeutics aims to address with its research.
seekingalpha
9.0
06-24seekingalpha
Cognition Therapeutics Aligns with FDA on Key Trial Aspects for Dementia Drug
  • Key FDA Agreement: Cognition Therapeutics has reached an agreement with the FDA confirming that the design of its registrational trial for psychosis associated with Lewy body dementia is appropriate, paving the way for future drug applications.
  • Clinical Trial Timeline: The company plans to initiate its registrational program for its lead asset zervimesine in mid-2027, marking a significant step towards a new drug application and potentially enhancing its market position in dementia treatment.
  • Approval Outcome Recognition: Written feedback from the FDA confirms that psychosis related to Lewy body dementia could be an approvable outcome for the pivotal study, providing strong support for Cognition Therapeutics' clinical trial and potentially accelerating the drug's market entry.
  • Executive Commentary: Chief Medical Officer Anthony Caggiano stated that this agreement with the FDA represents an important milestone, indicating that the company’s trial design has received regulatory endorsement, thereby boosting investor confidence in future developments.
Newsfilter
9.0
06-24Newsfilter
Cognition Therapeutics Receives FDA Feedback for DLB Psychosis Clinical Trial Plans
  • Positive FDA Feedback: Cognition Therapeutics received written feedback from the FDA confirming alignment on key aspects of their pivotal trial design, indicating that psychosis associated with dementia with Lewy bodies (DLB) could be an approvable outcome, marking a significant step towards a New Drug Application (NDA).
  • Clinical Trial Design: The Phase 3 clinical trial, expected to begin in mid-2027, will enroll DLB patients experiencing hallucinations and delusions, comparing 100 mg of zervimesine against a placebo over nine months, aiming to validate its efficacy in treating these symptoms.
  • Significant Efficacy: In the previous Phase 2 'SHIMMER' trial, zervimesine demonstrated an impressive 89% reduction in the progression of hallucinations and delusions among DLB patients, providing new hope for effective treatment options in this underserved population.
  • Urgent Market Need: With no FDA-approved drugs for DLB and the risks associated with traditional antipsychotics, the development of zervimesine addresses a critical unmet need, potentially transforming the treatment landscape for patients suffering from debilitating psychosis.
Newsfilter
8.5
06-16Newsfilter
Cognition Therapeutics Receives Patent Allowance for Zervimesine
  • Patent Allowance Granted: Cognition Therapeutics has received a Notice of Allowance from the USPTO for its lead drug candidate zervimesine (CT1812), which will protect this key formulation until 2045, and potentially until 2050 with a standard 5-year extension, significantly enhancing the company's market position in neurodegenerative disease treatments.
  • Innovative Production Process: The patent covers not only the composition of zervimesine but also a proprietary production process that provides a more favorable pharmaceutical profile, improving its competitiveness in treating diseases like Alzheimer's and dementia with Lewy bodies.
  • Clinical Trial Plans: Cognition Therapeutics plans to utilize this new form of zervimesine in upcoming registrational trials, particularly for treating psychosis in dementia with Lewy bodies, which is expected to offer new therapeutic options and fill a significant market gap.
  • R&D Funding Support: The company has secured nearly $200 million in grants from the National Institutes of Health and related foundations to support its clinical research in neurodegenerative diseases, demonstrating its strong capabilities and market potential in innovative drug development.
Newsfilter
8.5
06-01Newsfilter
Cognition Therapeutics CEO to Present at Financial Conferences
  • CEO Conference Presentation: Cognition Therapeutics' CEO Lisa Ricciardi is set to present at the Jefferies Global Healthcare Conference on June 4, 2026, where she will provide updates on the company's registration program for DLB psychosis, enhancing investor confidence in the company's future prospects.
  • Webcast Availability: Ricciardi's presentations will be available via live and archived webcasts on the company's Investor Relations website, ensuring that a broad audience of investors and stakeholders can access critical information, thereby improving the company's transparency and market awareness.
  • Clinical Research Progress: Cognition Therapeutics is advancing its lead candidate zervimesine (CT1812) in clinical trials, which has shown promising tolerability and efficacy signals in patients with DLB and mild-to-moderate Alzheimer's disease, potentially opening new market opportunities for the company.
  • Funding Support Background: The company has secured nearly $200 million in grants from the National Institutes of Health and related foundations to support its research in neurodegenerative diseases, underscoring its leadership position and ongoing innovation capabilities in the industry.
Wall Street analysts forecast CGTX stock price to rise
2 Analyst Rating
Wall Street analysts forecast CGTX stock price to rise
2 Buy
0 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
3.00
Averages
3.00
High
3.00
Current: 0.000
sliders
Low
3.00
Averages
3.00
High
3.00
B. Riley
B. Riley
Buy
maintain
$2 -> $3
AI Analysis
2025-11-21
Reason
B. Riley
B. Riley
Price Target
$2 -> $3
AI Analysis
2025-11-21
maintain
Buy
Reason
B. Riley raised the firm's price target on Cognition Therapeutics to $3 from $2 and keeps a Buy rating on the shares. Cognition's Phase 2 START trial for early Alzheimer's has fully enrolled 540 patients, reinforcing momentum from prior positive Phase 2b results and rising investigator interest in oral zervimesine, the analyst tells investors in a research note. With an 18-month primary endpoint and allowance for combination therapy, the trial design offers meaningful de-risking ahead of a mid-to-late 2027 readout, the firm adds.

Valuation Metrics

The current forward P/E ratio for Cognition Therapeutics Inc (CGTX.O) is 0.00, compared to its 5-year average forward P/E of -2.74. For a more detailed relative valuation and DCF analysis to assess Cognition Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.74
Current PE
0.00
Overvalued PE
-0.26
Undervalued PE
-5.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
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Quarterly

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Frequently Asked Questions

What is Cognition Therapeutics Inc (CGTX) stock price today?

The current price of CGTX is 1.08 USD — it has increased 0.93

What is Cognition Therapeutics Inc (CGTX)'s business?

Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. The Company is investigating its lead candidate, zervimesine (CT1812), in clinical programs in dementia with Lewy bodies (DLB) and Alzheimer’s disease. Its CT1812 and pipeline of sigma-2 modulators can regulate pathways that are impaired in these diseases for the treatment of degenerative diseases. Its lead product candidate, CT1812, is an orally delivered, small molecule designed to protect neuronal synapses by preventing the binding of oligomers of pathogenic proteins. Its pipeline candidates were discovered using proprietary biology and chemistry platforms designed to identify novel drug targets and disease-modifying therapies that address dysregulated pathways. It is developing other product candidates in the area of synucleinopathies.

What is the price predicton of CGTX Stock?

Wall Street analysts forecast CGTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CGTX is3.00 USD with a low forecast of 3.00 USD and a high forecast of 3.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Cognition Therapeutics Inc (CGTX)'s revenue for the last quarter?

Cognition Therapeutics Inc revenue for the last quarter amounts to -8.82M USD, decreased -35.99

What is Cognition Therapeutics Inc (CGTX)'s earnings per share (EPS) for the last quarter?

Cognition Therapeutics Inc. EPS for the last quarter amounts to USD, decreased

How many employees does Cognition Therapeutics Inc (CGTX). have?

Cognition Therapeutics Inc (CGTX) has 14 emplpoyees as of July 08 2026.

What is Cognition Therapeutics Inc (CGTX) market cap?

Today CGTX has the market capitalization of 96.66M USD.