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PALI Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
2.170
Open
2.160
VWAP
2.08
Vol
4.61M
Mkt Cap
354.10M
Low
1.990
Amount
9.61M
EV/EBITDA(TTM)
--
Total Shares
173.58M
EV
231.89M
EV/OCF(TTM)
--
P/S(TTM)
--
Palisade Bio, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing and advancing therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company’s lead product candidate, PALI-2108, is being developed as a treatment for patients living with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Fibrostenotic Crohn’s disease (FSCD). The Company is conducting a Phase I human clinical trial of its lead product candidate, PALI-2108, for the treatment of UC. In UC mouse models, the Company has demonstrated the dose-dependent efficacy of PALI-2108. It utilizes dextran sodium sulfate (DSS)-induced UC mouse models and targets engagement in oxazolone-induced colitis. PALI-2108 targets the key phosphodiesterase-4 (PDE4) in colon tissues and prevents it from breaking down cyclic Adenosine Monophosphate (cAMP) molecules which regulate inflammation in the body.
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Events Timeline

(ET)
2026-06-29
16:30:00
Major Averages Finish Broadly Higher as Investors Await Middle East News
select
2026-06-29
12:00:00
Major Averages Broadly Higher as Investors Await Middle East News
select
2026-06-29
09:30:00
Palisade Bio Receives FDA Clearance for PALI-2108 to Enter Phase 2 Trials
select
2026-05-12 (ET)
2026-05-12
17:30:00
Palisade Bio Files $300M Mixed Securities Shelf
select
2026-03-30 (ET)
2026-03-30
16:20:00
Palisade Bio Announces PALI-2108 Clinical Data
select
2026-02-23 (ET)
2026-02-23
08:50:00
Palisade Bio Presents New Data for PALI-2108 at ECCO Congress
select

News

stocktwits
9.0
06-29stocktwits
Palisade Bio Receives FDA Approval for Clinical Trial
  • FDA Approval for Trials: Palisade Bio received FDA clearance to initiate the global Phase 2 Ascentra-UC study targeting moderately to severely active ulcerative colitis patients, with plans to enroll 204 participants, highlighting the company's advancements in chronic bowel disease research.
  • Significant Stock Surge: Following the FDA approval announcement, Palisade Bio's shares surged over 17%, marking the largest single-day gain in seven months and reaching their highest levels in nearly two months, reflecting strong market confidence in the new drug.
  • Increased R&D Expenses: The company's Q1 report indicated that research and development expenses for PALI-2108 rose significantly from $1 million to $6.4 million year-over-year, demonstrating a heightened investment in clinical trials that is expected to support key data readouts for ulcerative colitis in 2027 and Crohn's disease in early 2028.
  • Optimistic Market Sentiment: Following the FDA approval, retail sentiment for Palisade Bio on Stocktwits shifted from 'bullish' to 'extremely bullish', with users anticipating the stock could exceed $3, despite a 12% decline this year, indicating a notable increase in positive market expectations for the future.
NASDAQ.COM
9.0
06-29NASDAQ.COM
Palisade Bio Receives FDA Clearance for Clinical Trial Initiation
  • FDA IND Approval: Palisade Bio's PALI-2108 has received FDA clearance for its Investigational New Drug application to treat moderately to severely active ulcerative colitis, enabling the initiation of the global Phase 2 ASCENTRA-UC clinical trial, marking a significant milestone in its development process.
  • Trial Design: The ASCENTRA-UC will be a multicenter, randomized, double-blind, placebo-controlled Phase 2 trial designed to enroll up to 204 patients, evaluating the efficacy, safety, and pharmacokinetics of PALI-2108, which is expected to provide critical data for future treatment options.
  • Key Milestones: The first patient enrollment is anticipated in the second half of 2026, with primary efficacy results expected in the second half of 2027, establishing a timeline that will support Palisade Bio's further development in the ulcerative colitis space.
  • Future Development Plans: In addition to ASCENTRA-UC, Palisade Bio plans to submit an IND application for Crohn's disease in the second half of 2026, demonstrating the company's ongoing commitment and strategic positioning in the treatment of gastrointestinal diseases.
Newsfilter
9.0
06-29Newsfilter
Palisade Bio Receives FDA Approval for UC Clinical Trial
  • Clinical Trial Launch: Palisade Bio announced that its IND application for PALI-2108 has been cleared by the FDA, with patient enrollment for the ASCENTRA-UC trial expected to begin in the second half of 2026, marking a significant advancement in the company's inflammatory bowel disease portfolio.
  • Trial Design Highlights: The ASCENTRA-UC trial will utilize a randomized, double-blind, placebo-controlled design, primarily assessing clinical remission at 12 weeks, indicating PALI-2108's potential in treating ulcerative colitis and offering new therapeutic options for patients.
  • Partnership Strategy: To ensure the successful execution of ASCENTRA-UC, Palisade Bio has partnered with PSI, a leading global contract research organization, leveraging its extensive experience in immunology and gastroenterology to enhance the likelihood of clinical trial success.
  • Future Development Plans: Palisade Bio also plans to submit an IND application for ASCENTRA-CD in the second half of 2026, demonstrating the company's confidence in expanding PALI-2108's applications across inflammatory bowel disease indications, potentially opening up broader market opportunities.
Yahoo Finance
8.5
05-21Yahoo Finance
B Group Acquires Stake in Bright Minds Biosciences
  • New Investment Position: B Group disclosed in its May 15, 2026 SEC filing that it acquired 67,500 shares of Bright Minds Biosciences for an estimated $5.43 million, indicating confidence in the company's future growth potential.
  • Significant Stake: This acquisition represents approximately 4% of B Group's reportable AUM, reflecting its strategic positioning within the biotechnology sector.
  • Strong Market Performance: Bright Minds' shares have surged nearly 175% over the past year, significantly outperforming the S&P 500's 25% increase, highlighting market confidence in its drug development prospects.
  • Increased R&D Investment: Bright Minds ramped up its R&D spending to C$18.7 million in the first half of fiscal 2026, a substantial increase from C$3.6 million a year earlier, demonstrating accelerated efforts in developing its lead drug BMB-101 for drug-resistant epilepsy.
Newsfilter
1.0
04-08Newsfilter
Palisade Bio Schedules Virtual Presentation at Needham Healthcare Conference
  • Virtual Presentation Scheduled: Palisade Bio will present virtually at the Needham & Co. 25th Annual Healthcare Conference on April 16, 2026, from 2:15 PM to 2:55 PM ET, showcasing its innovative drug development in inflammatory and fibrotic diseases.
  • Management Engagement: CEO JD Finley and CMO Dr. Mitchell Jones will participate in the conference, engaging in one-on-one meetings with registered investors post-presentation, enhancing transparency and interaction with the investment community.
  • Product Development Progress: The company's lead program, PALI-2108, is a once-daily oral PDE4 inhibitor prodrug designed for selective bioactivation in the ileum and colon, enabling targeted inhibition at disease sites while improving patient convenience and tolerability.
  • Clinical Study Plans: Palisade is advancing towards a Phase 2 clinical study in ulcerative colitis, aimed at evaluating clinical remission, response, and pharmacodynamic biomarkers over 12 weeks, with an extension phase to assess maintenance of remission, highlighting its potential in chronic disease treatment.
seekingalpha
9.0
03-31seekingalpha
Palisade Bio Reports Early Trial Data for PALI-2108 in Crohn’s Disease
  • Clinical Trial Progress: Palisade Bio reported two weeks of data from its early-stage trial of PALI-2108 for fibrostenotic Crohn’s disease, indicating endoscopic response rates comparable to AbbVie's Skyrizi and Rinvoq, highlighting its therapeutic potential.
  • Safety Profile: The therapy showed no serious adverse events among five patients, and the experimental treatment was well tolerated, demonstrating its safety for clinical application.
  • Follow-up Research Plans: Palisade Bio intends to launch a Phase 2 study to further evaluate PALI-2108's efficacy in moderate to severe Crohn’s disease patients, reflecting the company's confidence in the drug's future market potential.
  • Market Outlook: Palisade Bio is viewed as an undervalued biotech firm with blockbuster drug development potential, leading to optimistic market sentiment regarding its future performance.
Wall Street analysts forecast PALI stock price to rise
4 Analyst Rating
Wall Street analysts forecast PALI stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
7.00
Averages
13.00
High
25.00
Current: 0.000
sliders
Low
7.00
Averages
13.00
High
25.00
Wolfe Research
Andy Chen
Outperform
initiated
$7
AI Analysis
2026-04-08
Reason
Wolfe Research
Andy Chen
Price Target
$7
AI Analysis
2026-04-08
initiated
Outperform
Reason
Wolfe Research analyst Andy Chen initiated coverage of Palisade Bio with an Outperform rating and $7 price target. The firm sees a "quiet 2026," but is bullish into ulcerative colitis data due in the second half of 2027 with the mechanism and the firm's analyses supporting a favorable outcome despite mixed drug class data in the same indication, the analyst tells investors.
Clear Street
Buy
maintain
$12
2026-03-31
Reason
Clear Street
Price Target
$12
2026-03-31
maintain
Buy
Reason
Clear Street keeps a Buy rating and $12 price target on Palisade Bio, saying the decline in the stock price after the Phase 1B Clinical Study of PALI-2108 in Fibrostenotic Crohn's Disease looks misaligned with fundamentals. Together with previously disclosed UC data, the findings provide compelling validation and a strong foundation for PALI-2108's success, and the stock price decline is more timing-driven than data-driven, the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for Palisade Bio Inc (PALI.O) is 0.00, compared to its 5-year average forward P/E of -1.38. For a more detailed relative valuation and DCF analysis to assess Palisade Bio Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.38
Current PE
0.00
Overvalued PE
0.51
Undervalued PE
-3.27

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
8.84
Current PS
0.00
Overvalued PS
31.08
Undervalued PS
-13.40

Financials

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Whales Holding PALI

C
Commodore Capital LP
Holding
PALI
+20.80%
3M Return
R
RA Capital Management, L.P.
Holding
PALI
+13.65%
3M Return
E
Eversept Partners, L.P.
Holding
PALI
+9.12%
3M Return

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Frequently Asked Questions

What is Palisade Bio Inc (PALI) stock price today?

The current price of PALI is 2.09 USD — it has increased 2.45

What is Palisade Bio Inc (PALI)'s business?

Palisade Bio, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing and advancing therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company’s lead product candidate, PALI-2108, is being developed as a treatment for patients living with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Fibrostenotic Crohn’s disease (FSCD). The Company is conducting a Phase I human clinical trial of its lead product candidate, PALI-2108, for the treatment of UC. In UC mouse models, the Company has demonstrated the dose-dependent efficacy of PALI-2108. It utilizes dextran sodium sulfate (DSS)-induced UC mouse models and targets engagement in oxazolone-induced colitis. PALI-2108 targets the key phosphodiesterase-4 (PDE4) in colon tissues and prevents it from breaking down cyclic Adenosine Monophosphate (cAMP) molecules which regulate inflammation in the body.

What is the price predicton of PALI Stock?

Wall Street analysts forecast PALI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PALI is13.00 USD with a low forecast of 7.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Palisade Bio Inc (PALI)'s revenue for the last quarter?

Palisade Bio Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Palisade Bio Inc (PALI)'s earnings per share (EPS) for the last quarter?

Palisade Bio Inc. EPS for the last quarter amounts to -0.05 USD, decreased -89.36

How many employees does Palisade Bio Inc (PALI). have?

Palisade Bio Inc (PALI) has 14 emplpoyees as of July 07 2026.

What is Palisade Bio Inc (PALI) market cap?

Today PALI has the market capitalization of 354.10M USD.