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GHRS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
27.100
Open
26.180
VWAP
26.49
Vol
155.27K
Mkt Cap
1.80B
Low
25.470
Amount
4.11M
EV/EBITDA(TTM)
--
Total Shares
68.61M
EV
1.58B
EV/OCF(TTM)
--
P/S(TTM)
--
GH Research PLC is a clinical-stage biopharmaceutical company. The Company is focusing on developing its novel and proprietary mebufotenin therapies for the treatment of patients with treatment-resistant depression (TRD). Its portfolio includes GH001, its proprietary inhalable mebufotenin product candidate and GH002, its proprietary intravenous mebufotenin product candidate. GH001 is delivered via a vaporization device produced by a third party, and the Company is developing a proprietary aerosol delivery device which is in clinical investigation in Europe. GH001 completed two Phase 1 clinical trials in healthy volunteers, a Phase 1/2 trial in TRD and two Phase 2a proof-of-concept trials. GH002 Completed a randomized, double-blind, placebo-controlled, dose-ranging clinical pharmacology trial of GH002 in healthy volunteers, and it is developing GH002 within its focus area of psychiatric and neurological disorders.
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Events Timeline

(ET)
2026-06-04
10:40:00
GH Research Publishes Phase 2a Trial Results for Postpartum Depression
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2026-05-21 (ET)
2026-05-21
11:30:00
Enveric Biosciences Reports Q1 Earnings with Cash Balance of Approximately $10.3M
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2026-05-14 (ET)
2026-05-14
11:20:00
GH Research Reports Q1 Loss of 26 Cents, Cash at $267.3M
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2026-05-14
09:30:00
GH Research Files $400M Mixed Securities Shelf
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2026-05-14
07:30:00
Progress on Global GH001 Phase 3 Program as Planned
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2026-04-20 (ET)
2026-04-20
16:30:00
Major Averages Decline Amid Escalating Tensions with Iran
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News

Newsfilter
8.5
06-30Newsfilter
Rapid Growth in Major Depressive Disorder Treatment Market
  • Market Growth Potential: The global Major Depressive Disorder treatment market is projected to grow from approximately $20 billion in 2026 to nearly $36 billion by 2033, reflecting strong long-term demand and attracting billions in investment.
  • Clinical Trial Progress: Helus Pharma's HLP003 has surpassed 88% enrollment in the Phase 3 APPROACH study for MDD, with topline data expected in Q4 2026, marking a significant step towards commercialization.
  • Significant Efficacy: Phase 2 data for HLP003 demonstrated a ~23-point reduction in MADRS score at 12 months after two 16mg doses, achieving a 100% response rate and 71% remission rate, indicating its potential in treating treatment-resistant depression.
  • Strategic Partnerships: Helus Pharma has partnered with TARA Mind to enhance access to mental health treatment for veterans and collaborates with leading mental health organizations to support HLP003 Phase 3 recruitment, further expanding its market impact.
PRnewswire
8.5
06-26PRnewswire
Helus Pharma's HLP003 Phase 3 Trial Enrollment Surpasses 86%
  • Enrollment Milestone: Helus Pharma's HLP003 Phase 3 trial has surpassed 86% enrollment, keeping the FDA Breakthrough-designated program on track for a topline data readout in Q4 2026, indicating the company's potential in the mental health treatment space.
  • Clinical Trial Significance: Eric So noted that the continued enrollment progress underscores the execution of the clinical program, bringing them closer to the anticipated topline data release, which could provide a transformative treatment option for patients with major depressive disorder, enhancing the company's position in a competitive market.
  • FDA Breakthrough Designation: HLP003 has received FDA Breakthrough Therapy Designation, aimed at expediting development and review, signaling significant improvement potential in treating major depressive disorder, thus boosting investor confidence in the program.
  • Strong Market Demand: Major depressive disorder affects hundreds of millions globally, with traditional treatments offering limited relief; if HLP003 can validate its efficacy in Phase 3 trials, it could reshape the management of depression.
Newsfilter
8.5
06-26Newsfilter
Helus Pharma's HLP003 Phase 3 Trial Surpasses 86% Enrollment
  • Significant Trial Progress: Helus Pharma's HLP003 Phase 3 trial has surpassed 86% enrollment, keeping the FDA Breakthrough Therapy program on track for a topline data readout in Q4 2026, potentially offering a new treatment option for depression.
  • Clinical Data Highlights: HLP003 demonstrated substantial efficacy in Phase 2 trials, with a ~23-point reduction in MADRS scores at 12 months, and an 18-week response rate of 75%, improving to 100% at 12 months, laying a solid foundation for the upcoming Phase 3 trial.
  • Strong Market Demand: With millions affected by major depressive disorder and existing treatments often inadequate, HLP003's fast-acting, neuroplasticity-oriented approach could reshape depression management, addressing the urgent need for novel therapies in the market.
  • Far-reaching Strategic Implications: The Breakthrough Therapy designation accelerates HLP003's development, positioning Helus Pharma to carve out a niche in a competitive landscape, and successful Phase 3 data could pave the way for future commercialization efforts.
NASDAQ.COM
9.0
06-05NASDAQ.COM
GH Research Announces Phase 2a Results for GH001 in Treating Post-Partum Depression
  • Clinical Trial Results: GH Research PLC's Phase 2a trial results for GH001 indicate a significant average reduction of 35.4 points in depression scores among 10 postpartum depression patients over 8 days, demonstrating the drug's efficacy in alleviating postpartum depression symptoms.
  • Rapid Relief Effect: Remarkably, 100% of patients achieved remission (MADRS below 10) within two hours of dosing, showcasing GH001's rapid action mechanism and potentially offering a new solution for postpartum depression treatment.
  • Improvement in Maternal Functioning: The study also noted an average increase of 34.1 points in maternal functioning assessments, indicating GH001's positive impact on overall maternal well-being, further supporting its clinical application potential.
  • Future Research Plans: GH Research stated that these results support further investigation of inhaled mebufotenin in larger randomized controlled trials, highlighting the company's strategic focus on addressing treatment-resistant depression.
seekingalpha
9.5
05-14seekingalpha
GH Research Reports Strong Cash Position Amid Q1 Loss
  • Financial Performance: GH Research reported a Q1 GAAP EPS of -$0.31, indicating a loss; however, the company maintains a strong cash flow, reflecting ongoing investment in R&D.
  • Cash Reserves: As of March 31, 2026, GH Research holds $267.3 million in cash, cash equivalents, and marketable securities, ensuring financial flexibility for future project advancements.
  • Capital Raising: The company secured an additional $111.2 million in net cash proceeds from an underwritten offering in April 2026, which will support the advancement of GH001 into Phase 3 clinical trials, enhancing its market competitiveness.
  • Market Outlook: With Trump signing legislation to expedite PTSD research, GH Research's prospects in psychedelic treatments, particularly for depression, appear promising, potentially opening new avenues for growth.
seekingalpha
8.5
04-29seekingalpha
GH Research Prices $117.5 Million Stock Offering
  • Stock Offering Pricing: GH Research has priced an underwritten offering of 6.53 million ordinary shares at $18 each, aiming for gross proceeds of approximately $117.5 million, which will significantly bolster the company's financial resources for future initiatives.
  • Underwriter Participation: The transaction was initiated by Lynx1 Capital Management, with participation from Deep Track Capital and Foresite Capital, while Stifel, Cantor Fitzgerald, and RBC Capital Markets serve as joint book-running managers, reflecting strong market confidence in the company.
  • Closing Schedule: The offering is expected to close on April 30, indicating the company's active engagement in capital markets and urgent funding needs, which may influence the advancement of its upcoming projects.
  • Market Reaction: Despite a 1% decline in GH Research's shares during premarket trading, the offering is still viewed as a positive step towards enhancing the company's financial position, potentially boosting investor confidence in the long run.
Wall Street analysts forecast GHRS stock price to rise
6 Analyst Rating
Wall Street analysts forecast GHRS stock price to rise
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
19.00
Averages
28.60
High
35.00
Current: 0.000
sliders
Low
19.00
Averages
28.60
High
35.00
H.C. Wainwright
Buy
downgrade
$70 -> $65
AI Analysis
2026-05-19
Reason
H.C. Wainwright
Price Target
$70 -> $65
AI Analysis
2026-05-19
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on GH Research to $65 from $70 and keeps a Buy rating on the shares. The firm cites share count dilution from the company's April offering for the target cut.
Cantor Fitzgerald
NULL
to
Overweight
maintain
$25 -> $35
2026-05-15
Reason
Cantor Fitzgerald
Price Target
$25 -> $35
2026-05-15
maintain
NULL
to
Overweight
Reason
Cantor Fitzgerald raised the firm's price target on GH Research to $35 from $25 and keeps an Overweight rating on the shares. GH Research is viewed as operating in a large and expanding psychedelic therapy market with significant unmet mental health need, where long-term peak sales across related treatments could reach roughly $50B, supporting a constructive demand backdrop despite ongoing uncertainty around competitive dynamics in the space, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for GHRS
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Valuation Metrics

The current forward P/E ratio for GH Research PLC (GHRS.O) is 0.00, compared to its 5-year average forward P/E of -19.07. For a more detailed relative valuation and DCF analysis to assess GH Research PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-19.07
Current PE
0.00
Overvalued PE
-3.39
Undervalued PE
-34.74

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-8.55
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-3.06
Undervalued EV/EBITDA
-14.04

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

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Whales Holding GHRS

B
BVF Partners L.P.
Holding
GHRS
+22.90%
3M Return
A
Avoro Capital Advisors LLC
Holding
GHRS
+17.05%
3M Return
R
RA Capital Management, L.P.
Holding
GHRS
+13.65%
3M Return
C
Cormorant Asset Management, LP
Holding
GHRS
+3.97%
3M Return

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Frequently Asked Questions

What is GH Research PLC (GHRS) stock price today?

The current price of GHRS is 26.89 USD — it has increased 2.75

What is GH Research PLC (GHRS)'s business?

GH Research PLC is a clinical-stage biopharmaceutical company. The Company is focusing on developing its novel and proprietary mebufotenin therapies for the treatment of patients with treatment-resistant depression (TRD). Its portfolio includes GH001, its proprietary inhalable mebufotenin product candidate and GH002, its proprietary intravenous mebufotenin product candidate. GH001 is delivered via a vaporization device produced by a third party, and the Company is developing a proprietary aerosol delivery device which is in clinical investigation in Europe. GH001 completed two Phase 1 clinical trials in healthy volunteers, a Phase 1/2 trial in TRD and two Phase 2a proof-of-concept trials. GH002 Completed a randomized, double-blind, placebo-controlled, dose-ranging clinical pharmacology trial of GH002 in healthy volunteers, and it is developing GH002 within its focus area of psychiatric and neurological disorders.

What is the price predicton of GHRS Stock?

Wall Street analysts forecast GHRS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GHRS is28.60 USD with a low forecast of 19.00 USD and a high forecast of 35.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is GH Research PLC (GHRS)'s revenue for the last quarter?

GH Research PLC revenue for the last quarter amounts to -18.75M USD, increased 47.03

What is GH Research PLC (GHRS)'s earnings per share (EPS) for the last quarter?

GH Research PLC. EPS for the last quarter amounts to -10732000.00 USD, increased 25.13

How many employees does GH Research PLC (GHRS). have?

GH Research PLC (GHRS) has 73 emplpoyees as of July 07 2026.

What is GH Research PLC (GHRS) market cap?

Today GHRS has the market capitalization of 1.80B USD.