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MDGL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
554.005
Open
534.960
VWAP
543.05
Vol
318.42K
Mkt Cap
12.57B
Low
529.800
Amount
172.92M
EV/EBITDA(TTM)
--
Total Shares
23.06M
EV
11.73B
EV/OCF(TTM)
--
P/S(TTM)
11.30
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
Show More

Events Timeline

(ET)
2026-05-27
08:20:00
Madrigal Pharmaceuticals Shows Rezdiffra Reduces Cardiovascular Risk in MASH Patients
select
2026-05-06 (ET)
2026-05-06
07:40:00
Madrigal Reports Q1 Revenue of $311.34M, Beating Expectations
select
2026-05-05 (ET)
2026-05-05
08:10:00
Arrowhead Signs Exclusive License Agreement with Madrigal for ARO-PNPLA3
select

News

PRnewswire
7.5
07-02PRnewswire
Ribo and Madrigal Achieve siRNA Drug Milestone
  • Candidate Nomination Success: Suzhou Ribo Life Science and Madrigal Pharmaceuticals have successfully nominated their first drug candidate in their siRNA partnership, marking a significant milestone that is expected to expedite the IND application process for clinical studies.
  • Focus on MASH Treatment: This collaboration targets metabolically driven steatohepatitis (MASH), an area with substantial unmet medical needs, and aims to develop innovative RNA therapeutics to address this condition.
  • Complementary Technical Strengths: Ribo's expertise in siRNA drug research and delivery technology, combined with Madrigal's market leadership in MASH, has facilitated rapid project advancement, showcasing the synergistic effects of their collaboration in drug development.
  • Global Patient Benefit: Both parties are committed to advancing the development of novel siRNA candidates, aiming to provide new treatment options for MASH patients worldwide, reflecting their dedication to addressing significant health challenges.
PRnewswire
7.5
07-02PRnewswire
Ribo Life Science and Madrigal Achieve Key Collaboration Milestone
  • Candidate Drug Nomination: Suzhou Ribo Life Science and Madrigal Pharmaceuticals have successfully achieved a candidate drug nomination milestone in their siRNA collaboration, highlighting their joint commitment to advancing therapies for metabolic-associated liver diseases.
  • Clinical Research Preparation: This milestone will facilitate the immediate initiation of preclinical studies necessary for the clinical trial application, expected to provide new treatment options for global MASH patients, addressing significant unmet medical needs.
  • Complementary Technical Strengths: Ribo's leading capabilities in siRNA drug discovery and delivery technology, combined with Madrigal's clinical expertise in MASH, create a robust foundation for collaboration, accelerating project progress.
  • Global Market Potential: This partnership not only expands the therapeutic landscape for MASH but also demonstrates both parties' determination to drive innovative therapies globally, aiming to deliver more effective treatment solutions for patients.
PRnewswire
7.5
07-02PRnewswire
Ribo Life Science and Madrigal Advance Drug Development Collaboration
  • Collaboration Milestone: Suzhou Ribo Life Science and Madrigal Pharmaceuticals have successfully designated their first drug candidate, marking a significant advancement in their partnership focused on RNA interference therapies, which is expected to accelerate the initiation of new drug research to meet urgent liver disease treatment needs.
  • Clinical Trial Preparation: This collaboration will immediately launch new drug studies aimed at supporting upcoming clinical trials, particularly targeting metabolic dysfunction-associated steatohepatitis (MASH), addressing the unmet medical needs in this area.
  • Complementary Technical Strengths: Ribo's world-class capabilities in RNA interference drug discovery and delivery technology, combined with Madrigal's extensive clinical expertise in MASH, enable rapid project advancement, enhancing the efficiency of new therapy development.
  • Significant Market Potential: As the number of MASH patients rises, this partnership not only aids in developing innovative therapies but also has the potential to provide new treatment options for patients worldwide, further solidifying both companies' market positions in the biopharmaceutical sector.
Newsfilter
8.5
07-02Newsfilter
Ribo and Madrigal Achieve siRNA Drug Milestone
  • Milestone Achievement: Suzhou Ribo Life Science and Madrigal Pharmaceuticals have successfully reached the first candidate drug nomination milestone in their siRNA partnership, indicating efficient collaboration in liver disease treatment, with immediate initiation of IND-enabling studies to support clinical research.
  • Focus on MASH: This collaboration targets metabolic dysfunction-associated steatohepatitis (MASH), a field with significant unmet medical needs, and the joint efforts are expected to broaden therapeutic options for this condition, enhancing patient quality of life.
  • Complementary Strengths: Ribo's world-class capabilities in siRNA drug discovery and delivery technology, combined with Madrigal's market-leading clinical expertise in MASH, have accelerated project progress, highlighting the strategic importance of their partnership.
  • Commitment to Global Development: Ribo and its subsidiary Ribocure are dedicated to the global development of life-saving oligonucleotide therapies, leveraging innovative R&D capabilities to address real medical needs worldwide and advance clinical trials.
PRnewswire
8.5
07-02PRnewswire
Ribo Life Science and Madrigal Achieve Drug Candidate Milestone
  • Milestone Achievement: Suzhou Ribo Life Science and Madrigal Pharmaceuticals have successfully reached the first drug candidate nomination milestone in their siRNA partnership, indicating rapid progress in liver disease treatment and paving the way for the initiation of IND-enabling studies to accelerate clinical trials.
  • Complementary Strengths: Ribo's world-class capabilities in siRNA drug discovery and delivery technology, combined with Madrigal's market-leading clinical expertise in metabolic dysfunction-associated steatohepatitis (MASH), will expedite the development of novel therapies for this condition.
  • Significant Market Need: The collaboration addresses the tremendous unmet medical need in the MASH field, broadening the potential for liver-directed therapeutics and offering new treatment options for patients worldwide, reflecting both companies' commitment to innovative drug development.
  • Global Development Strategy: Ribo Life Science and its subsidiary Ribocure are dedicated to the global development of life-saving oligonucleotide therapies, leveraging a strong product pipeline and innovative capabilities to tackle serious diseases and successfully conduct clinical trials.
PRnewswire
8.5
07-02PRnewswire
Ribo Life Science and Madrigal Achieve Drug Candidate Milestone
  • Drug Candidate Milestone: Suzhou Ribo Life Science and Madrigal Pharmaceuticals have successfully achieved the first candidate drug nomination milestone, indicating efficient collaboration in their siRNA partnership, with immediate plans to initiate IND-enabling studies to support clinical research.
  • Focus on Liver Disease: This collaboration targets metabolic dysfunction-associated steatohepatitis (MASH), a field with significant unmet medical needs, and aims to enhance treatment options for patients suffering from this condition.
  • Complementary Technical Strengths: Ribo possesses world-class capabilities in siRNA drug discovery and delivery technology, while Madrigal has established a market-leading presence and profound clinical expertise in the MASH field, with their combined strengths accelerating project progress.
  • Global Development Strategy: Ribo and its subsidiary Ribocure are dedicated to the global development of life-saving oligonucleotide therapies, aiming to leverage innovative capabilities and clinical trials to advance siRNA drug development and address real unmet medical needs worldwide.
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
Wall Street analysts forecast MDGL stock price to rise
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
BofA
Neutral
maintain
$550 -> $542
AI Analysis
2026-06-11
Reason
BofA
Price Target
$550 -> $542
AI Analysis
2026-06-11
maintain
Neutral
Reason
BofA lowered the firm's price target on Madrigal Pharmaceuticals to $542 from $550 and keeps a Neutral rating on the shares. While Rezdiffra's launch in MASH has impressed, debate has shifted to whether it can sustain this pace, says the analyst, who lowered the firm's 2028 Rezdiffra revenue forecast to $2.6B from $2.7B following conversations with key opinion leaders and prior management feedback.
Truist
Buy
maintain
$640 -> $709
2026-05-13
Reason
Truist
Price Target
$640 -> $709
2026-05-13
maintain
Buy
Reason
Truist raised the firm's price target on Madrigal Pharmaceuticals to $709 from $640 and keeps a Buy rating on the shares. The firm's survey work reinforces its belief in the sizable MASH patient numbers eligible for treatment that will translate to significant Rezdiffra revenues for Madrigal, the analyst tells investors in a research note, adding that Truist is increasing the US peak MASH patients treated with Rezdiffra estimates to 193K from 158K prior.
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Valuation Metrics

The current forward P/E ratio for Madrigal Pharmaceuticals Inc (MDGL.O) is 666.67, compared to its 5-year average forward P/E of 81.53. For a more detailed relative valuation and DCF analysis to assess Madrigal Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
81.53
Current PE
666.67
Overvalued PE
337.44
Undervalued PE
-174.38

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-23.98
Current EV/EBITDA
-18.81
Overvalued EV/EBITDA
30.63
Undervalued EV/EBITDA
-78.59

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
48.37
Current PS
5.52
Overvalued PS
147.50
Undervalued PS
-50.77

Financials

AI Analysis
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Whales Holding MDGL

A
Armistice Capital LLC
Holding
MDGL
+20.55%
3M Return
H
Hood River Capital Management LLC
Holding
MDGL
+19.09%
3M Return
A
Avoro Capital Advisors LLC
Holding
MDGL
+17.64%
3M Return
A
Affinity Asset Advisors, LLC
Holding
MDGL
+15.41%
3M Return
J
Journey Strategic Wealth LLC
Holding
MDGL
+11.12%
3M Return
A
Alkeon Capital Management, LLC
Holding
MDGL
+10.76%
3M Return

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Frequently Asked Questions

What is Madrigal Pharmaceuticals Inc (MDGL) stock price today?

The current price of MDGL is 545.36 USD — it has increased 3

What is Madrigal Pharmaceuticals Inc (MDGL)'s business?

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).

What is the price predicton of MDGL Stock?

Wall Street analysts forecast MDGL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MDGL is636.22 USD with a low forecast of 527.00 USD and a high forecast of 900.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Madrigal Pharmaceuticals Inc (MDGL)'s revenue for the last quarter?

Madrigal Pharmaceuticals Inc revenue for the last quarter amounts to 311.34M USD, increased 126.84

What is Madrigal Pharmaceuticals Inc (MDGL)'s earnings per share (EPS) for the last quarter?

Madrigal Pharmaceuticals Inc. EPS for the last quarter amounts to -3.25 USD, decreased -2.11

How many employees does Madrigal Pharmaceuticals Inc (MDGL). have?

Madrigal Pharmaceuticals Inc (MDGL) has 915 emplpoyees as of July 08 2026.

What is Madrigal Pharmaceuticals Inc (MDGL) market cap?

Today MDGL has the market capitalization of 12.57B USD.